Neratinib (INN), sold under the brand name Nerlynx, is a tyrosine kinase inhibitor anti-cancer medication used for the treatment of breast cancer. The...
16 KB (1,300 words) - 02:35, 16 July 2024
in 2010. In August 2011 Puma licensed two drug candidates from Pfizer: neratinib (PB272) and an analog (PB357) to serve as a backup candidate.: 6, 23 ...
9 KB (798 words) - 07:15, 29 February 2024
afatinib, axitinib, brigatinib, baricitinib, cabozantinib, dasatinib, neratinib, eltrombopag, ibrutinib, lenvatinib, palbociclib, regorafenib, tofacitinib...
5 KB (232 words) - 10:23, 8 March 2024
expected to lead to a wider therapeutic index. The pan-ErbB inhibitor Neratinib was approved in the US in 2017 and in the EU in 2018 for the extended...
20 KB (2,061 words) - 05:47, 29 November 2023
anti-HER2 therapeutics are also tyrosine kinase inhibitors (Lapatinib, Neratinib, and Tucatinib) and antibody-drug conjugates (ado-trastuzumab emtansine...
43 KB (4,651 words) - 13:41, 27 July 2024
Canertinib Dacomitinib Erlotinib Gefitinib Grandinin Icotinib Lapatinib Neratinib Osimertinib Vandetanib WHI-P 154 Antibodies: Cetuximab Depatuxizumab Depatuxizumab...
121 KB (13,799 words) - 18:53, 22 October 2024
1-1% frequency) Keratitis Interstitial lung disease Like lapatinib and neratinib, afatinib is a protein kinase inhibitor that also irreversibly inhibits...
15 KB (1,122 words) - 15:16, 4 August 2024
first-generation inhibitors, researchers have used irreversible EGFR inhibitors like neratinib or dacomitinib, called tyrosine kinase inhibitors (TKIs). These new drugs...
21 KB (2,162 words) - 15:09, 19 August 2024
Canertinib Dacomitinib Erlotinib Gefitinib Grandinin Icotinib Lapatinib Neratinib Osimertinib Vandetanib WHI-P 154 Antibodies: Cetuximab Depatuxizumab Depatuxizumab...
92 KB (8,729 words) - 03:44, 26 October 2024
Canertinib Dacomitinib Erlotinib Gefitinib Grandinin Icotinib Lapatinib Neratinib Osimertinib Vandetanib WHI-P 154 Antibodies: Cetuximab Depatuxizumab Depatuxizumab...
31 KB (3,421 words) - 06:52, 2 November 2024