Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding...
22 KB (2,808 words) - 07:40, 8 October 2024
CD154 (redirect from Cd40 ligand)
CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules...
15 KB (1,744 words) - 02:28, 15 October 2024
which codes for CD40 ligand. This gene is located on the long arm of the X chromosome at position 26, denoted Xq26. Normally, CD40 ligand is expressed...
6 KB (745 words) - 20:15, 20 July 2024
several co-stimulatory molecules required for T cell activation, including CD40 and B7. The latter can interact with CD28 on the surface of a CD4+ T cell...
16 KB (2,128 words) - 09:55, 4 March 2024
Frexalimab (SAR441344) is a second-generation monoclonal antibody that inhibits CD40 ligand. It is in development by Sanofi for the treatment of relapsing multiple...
4 KB (271 words) - 11:52, 13 September 2024
recombination (Ig-CSR) deficiencies. The most common causes are mutations in the CD40 Ligand (CD40LG) gene located at Xq26.3-27 leading to X-linked HIGM (XHIGM)...
16 KB (1,719 words) - 09:42, 18 March 2024
activated CD4+ T cells and monocytes are in close contact, interaction of CD40-CD40L between these two cells and subsequent IFNγ secretion by the T cells...
3 KB (317 words) - 16:09, 26 September 2023
agonistic antibodies (e.g., anti-CD40) that are conjugated with antigen of interest. Multiple, next-generation anti-CD40 platforms are being actively developed...
59 KB (6,137 words) - 22:03, 11 October 2024
signaling pathway. Moreover, this protein is only used in cells expressing CD40 and CD40L, which are also from the tumor necrosis receptor superfamily and...
8 KB (1,120 words) - 00:22, 14 September 2024
interaction between B and T cells in the interfollicular area of the lymph node, CD40-CD40L ligation, NF-kB signaling and expression of IRF4 and BCL6. GC B cells...
22 KB (2,792 words) - 06:20, 3 March 2024