Cytotoxic T-lymphocyte associated protein 4, (CTLA-4) also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an...
30 KB (3,464 words) - 22:51, 24 May 2024
Hashimoto's thyroiditis (section CTLA-4 genes)
CTLA-4 gene polymorphisms may contribute to the reduced inhibition of T-cell proliferation and increase susceptibility to autoimmune response. CTLA-4...
72 KB (7,888 words) - 02:12, 28 August 2024
Checkpoint inhibitor (section CTLA-4 inhibitors)
It blocks the immune checkpoint molecule CTLA-4. Clinical trials have also shown some benefits of anti-CTLA-4 therapy on lung cancer or pancreatic cancer...
21 KB (2,093 words) - 02:41, 1 September 2024
antigen-presenting cells (APC) that, when paired with either a CD28 or CD152 (CTLA-4) surface protein on a T cell, can produce a costimulatory signal or a coinhibitory...
5 KB (637 words) - 09:45, 14 March 2022
Cancer immunotherapy (section CTLA-4 blockade)
blocks the immune checkpoint molecule CTLA-4. As of 2012, clinical trials have also shown some benefits of anti-CTLA-4 therapy on lung cancer or pancreatic...
92 KB (12,308 words) - 07:41, 15 September 2024
antibody medication that works to activate the immune system by targeting CTLA-4, a protein receptor that downregulates the immune system. Cytotoxic T lymphocytes...
47 KB (4,659 words) - 01:32, 18 May 2024
region of the immunoglobulin IgG1 fused to the extracellular domain of CTLA-4. In order for a T cell to be activated and produce an immune response, an...
9 KB (850 words) - 19:46, 17 July 2024
membrane protein of 288 amino acids. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. The protein's structure includes an extracellular...
39 KB (5,010 words) - 05:27, 17 August 2024
have lower levels of CTLA-4 than those with CTLA-4 haploinsufficiency, the condition frequently presents earlier in life. CTLA-4 haploinsufficiency results...
61 KB (5,487 words) - 04:55, 9 August 2024
tandem. Both CD80 and CD86 interact with costimulatory receptors CD28, CTLA-4 (CD152) and the p75 neurotrophin receptor. CD80 is a member of the B7 family...
20 KB (2,435 words) - 02:23, 1 September 2024