Lymphocyte-activation gene 3 (redirect from LAG3 (gene))
also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene. LAG3, which was discovered in 1990 and was designated CD223 (cluster of...
52 KB (6,646 words) - 14:14, 26 July 2024
company working primarily in the field of cancer immunotherapy using the LAG3 immune control mechanism. The company was originally built on CVac, a therapeutic...
15 KB (1,759 words) - 12:41, 3 September 2024
inhibitory receptor Lymphocyte-Activation Gene 3 (LAG3), yielding insights, notably demonstrating the role of LAG3 in regulating Treg activity and function. His...
30 KB (3,517 words) - 08:24, 3 July 2024
immune system. In tumors Th3 cells can express lymphocyte activation gene-3 (LAG3). Th3 cells produce vast amounts of TGF-β and to a lesser degree also the...
11 KB (1,235 words) - 01:34, 11 November 2023
Frédéric Triebel (section Work on LAG3 prior to 2001)
is a French immunologist who is best known for his 1990 discovery of the LAG3 immune control mechanism. Triebel worked through the 1990s in a collaboration...
10 KB (1,115 words) - 15:10, 23 June 2024
Bristol-Myers Squibb is working on Lirilumab, a monoclonal antibody to KIR. LAG3: short for Lymphocyte Activation Gene-3, works to suppress an immune response...
31 KB (3,467 words) - 01:27, 25 June 2024
receptor binding domain (RBD) of SARS-CoV-2 Y COVID-19 Relatlimab mab human LAG3 melanoma Remtolumab mab human IL-17A, TNF Reslizumab Cinqair mab humanized...
136 KB (4,020 words) - 07:14, 15 August 2024
cell membrane protein-3 (TIM3), and lymphocyte activation gene 3 protein (LAG3). Soluble molecules such as cytokines IL-10 or TGF-β are also able to trigger...
71 KB (9,026 words) - 12:33, 26 April 2024
HGNC:18512 Q53H82 8524 LACTBL1 HGNC:35445 A8MY62 8525 LAD1 HGNC:6472 O00515 8526 LAG3 HGNC:6476 P18627 8527 LAGE3 HGNC:26058 Q14657 8528 LAIR1 HGNC:6477 Q6GTX8...
277 KB (17 words) - 15:46, 9 May 2024
anti-PD-1 and PD-L1 drugs in combination with other immunotherapy drugs blocking LAG3, B7-H3, KIR, OX40, PARP, CD27, and ICOS. Pembrolizumab (Keytruda, formerly...
31 KB (3,266 words) - 05:29, 20 May 2024