The human gene SRD5A2 encodes the 3-oxo-5α-steroid 4-dehydrogenase 2 enzyme, also known as 5α-reductase type 2 (5αR2), one of three isozymes of 5α-reductase...

deficiency (5αR2D) is an autosomal recessive condition caused by a mutation in SRD5A2, a gene encoding the enzyme 5α-reductase type 2 (5αR2). The condition is...

There are three isozymes of 5α-reductase encoded by the genes SRD5A1, SRD5A2, and SRD5A3. 5α-Reductases catalyze the following generalized chemical reaction:...

(2004). "Testosterone enanthate therapy is effective and independent of SRD5A2 and AR gene polymorphisms in boys with micropenis". J. Urol. 172 (1): 319–24...

(type 1) and SRD5A2 (type 2), with the latter being the most biologically important isoenzyme. There is also third 5α-reductase: SRD5A3. SRD5A2 is most highly...

SRD5A1 and possibly, SRD5A2 enzymes. While the role of the SRD5A1 enzyme in this reaction is well established, it is unclear whether SRD5A2 is also involved...

androgen synthesis that bypasses testosterone as an intermediate product. SRD5A2 catalyzes the 5α-reduction of 11-ketotestosterone that terminates at 11-ketoandrosterone...

Sevim (2016). "Homozygous Ala65Pro Mutation with V89L Polymorphism in SRD5A2 Deficiency". Journal of Clinical Research in Pediatric Endocrinology. 8...

into the more potent androgen, 5α-dihydrotestosterone (DHT). The SRD5A1, SRD5A2, and SRD5A3 genes in humans all encode 5α-reductase isozymes. The 3-oxo-5α-steroid...

adrenal cortex into 21dF or 11OHP4, respectively, 5α-reduction by SRD5A1/SRD5A2, cleavage of a side-chain (C17-C20 bond) from the steroid nucleus by 17...