Tet methylcytosine dioxygenase 2 (redirect from TET2)
Tet methylcytosine dioxygenase 2 (TET2) is a human gene. It resides at chromosome 4q24, in a region showing recurrent microdeletions and copy-neutral loss...
25 KB (2,576 words) - 13:09, 21 January 2024
often associated with a somatic mutation, for example in the JAK2, CALR, TET2, and MPL gene markers. In rare cases, some MPNs such as primary myelofibrosis...
16 KB (1,524 words) - 20:11, 12 February 2024
The three related TET genes, TET1, TET2 and TET3 code respectively for three related mammalian proteins TET1, TET2, and TET3. All three proteins possess...
32 KB (3,984 words) - 05:42, 27 April 2024
from binding to and thereby activating the isolated TET2 protein in a cell-free system; b) TET2 gene knockout bone marrow-derived macrophages (i.e.,...
95 KB (11,779 words) - 02:34, 19 August 2024
oxidized by the ten-eleven translocation (TET) family of dioxygenases (TET1, TET2, TET3) to generate 5-hydroxymethylcytosine (5hmC). In successive steps TET...
29 KB (3,493 words) - 00:14, 22 June 2024
X-inactivation skew also had mutations in the hematologic-malignancy-associated gene TET2. In 2014, several independent studies confirmed the presence of malignancy-associated...
50 KB (5,831 words) - 11:09, 1 September 2024
However, evidence for similar general-acid catalysis of the k2 reaction (Tet2) has been controverted; apparently water provides a proton to the amine leaving...
11 KB (1,059 words) - 09:11, 4 August 2024
WT1 is mutated in a mutually exclusive manner with TET2, IDH1, and IDH2 in acute myeloid leukemia. TET2 can be recruited by WT1 to its target genes and activates...
27 KB (3,082 words) - 06:46, 13 July 2024
functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1". Leukemia. 24 (6): 1128–1138. doi:10.1038/leu...
27 KB (2,844 words) - 13:15, 3 August 2024
Mutations of CBL are found in approximately 5–18% of cases. Mutations in the TET2 gene are found in approximately 40–50% of CMML. Inactivating mutations in...
25 KB (2,922 words) - 14:19, 29 August 2023