Thiopurine methyltransferase or thiopurine S-methyltransferase (TPMT) is an enzyme that in humans is encoded by the TPMT gene. A pseudogene for this locus...

The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease...

especially common in people with a genetic deficiency of the enzyme thiopurine S-methyltransferase. Other serious risk factors include an increased risk of certain...

Examples of methyltransferase enzymes relevant to disease: thiopurine methyltransferase: defects in this gene causes toxic accumulation of thiopurine compounds...

deficiency in thiopurine S-methyltransferase are at higher risk of side effects. Use in pregnancy may harm the baby. Mercaptopurine is in the thiopurine and antimetabolite...

when on the medication. People with a genetic deficiency in thiopurine S-methyltransferase are at higher risk of side effects. Avoiding pregnancy when...

reduction of the thiopurine, usually to one-third of the standard dose depending upon the patient's genetic status for thiopurine methyltransferase. Allopurinol...

One of his early studies investigated the correlation between thiopurine methyltransferase genotype and azathioprine toxicity in rheumatic disease patients...

Q.; Pui, C. H.; Evans, W. E. (April 1, 1995). "Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts...

TPMT gene encodes for the thiopurine S-methyltransferase (TPMT) enzyme. It participates in the S-methylation of thiopurine drugs, which include 6-mercaptopurine...