Half maximal effective concentration (EC50) is a measure of the concentration of a drug, antibody or toxicant which induces a biological response halfway...
9 KB (1,024 words) - 06:20, 19 February 2024
IC50 is comparable to other measures of potency, such as EC50 for excitatory drugs. EC50 represents the dose or plasma concentration required for obtaining...
10 KB (1,072 words) - 06:17, 20 May 2024
inversely related to its half maximal effective concentration (EC50) value. The EC50 can be measured for a given agonist by determining the concentration...
14 KB (1,622 words) - 00:36, 7 July 2024
potential channels TRPA1 (EC50 = 700 nM), TRPV1 (EC50 = 1,300 nM), TRPV2 (EC50 = 1,720 nM), TRPV3 (EC50 = 1,000 nM), and TRPV4 (EC50 = 5,100 nM) (efficacy...
24 KB (1,983 words) - 20:31, 14 August 2024
the CB1 receptors with an EC50 of 44.4nM for 9R-HHCP and 134nM for 9S-HHCP. Compared to Hexahydrocannabinol (HHC) with an EC50 of 101nM for 9R-HHC and 1...
5 KB (450 words) - 04:15, 13 August 2024
as a strong non-competitive selective NMDA receptor antagonist, with an EC50 of 20 μM; which might promote sedation in addition with the strong antihistaminergic...
32 KB (2,680 words) - 07:25, 27 July 2024
as EC50, IC50, ED50, etc.) and measures of efficacy (such as tissue, cell or population response). A commonly used dose–response curve is the EC50 curve...
17 KB (1,788 words) - 12:43, 12 December 2023
Threshold dose (section EC50)
toxicology, there are some other safety factors including LD50, LC50 and EC50. Threshold dose is a dose of drug barely adequate to produce a biological...
23 KB (2,910 words) - 06:26, 27 September 2023
the 5-HT2A receptor, with an EC50 of 185.7 nM and an efficacy of 28.7% (vs 5-HT), and a full agonist at 5-HT2C with an EC50 of 89.7 nM and an efficacy of...
2 KB (121 words) - 00:40, 14 February 2024
eliciting 50% of its maximal effect (half maximal effective concentration = EC50) at the human 5-HT2A receptor in vitro are in the 0.118–0.983 μmol/L range...
144 KB (14,369 words) - 12:23, 21 August 2024