minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative...

72 polymorphisms, MDM2 SNP309, and A2164G may collectively be associated with non-oropharyngeal cancer susceptibility and that MDM2 SNP309 in combination...

unlike most neoplastic cell in the liposarcomas, do not overexpress the MDM2 gene); 2) atypical spindle cell lipomas (i.e. benign tumors with mildly atypical...

Nutlins are cis-imidazoline analogs which inhibit the interaction between mdm2 and tumor suppressor p53, and which were discovered by screening a chemical...

can regulate cytosolic protein localization. For example, the E3 ligase MDM2 ubiquitylates p53 either for degradation (K48 polyubiquitin chain), or for...

Brigimadlin (BI-907828) is a small molecule MDM2-TP53 inhibitor developed for liposarcoma. "Brigimadlin". pubchem.ncbi.nlm.nih.gov. Rinnenthal, Joerg;...

accumulates mainly in the nucleolus where it forms stable complexes with NPM or Mdm2. These interactions allow p14ARF to act as a tumor suppressor by inhibiting...

SWI/SNF complex assembly pathway. The protein domain, SWIB/MDM2, short for SWI/SNF complex B/MDM2 is an important domain. This protein domain has been found...

metal band My Dear Melancholy, an extended play by the Weeknd Mdm2 protein, encoded by the MDM2 gene in humans Medical decision-making, part of differential...

significant structural similarity to p53-binding protein MDM2 MDM4 has been shown to interact with E2F1, Mdm2 and P53. GRCh38: Ensembl release 89: ENSG00000198625...