• Thumbnail for Mothers against decapentaplegic homolog 3
    3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene. SMAD3 is a member of the SMAD family of proteins...
    33 KB (4,115 words) - 03:51, 11 September 2024
  • Thumbnail for Loeys–Dietz syndrome
    2, Type 3, Type 4 and Type 5 are caused by mutations in TGFBR1, TGFBR2, SMAD3, TGFB2, and TGFB3 respectively. These five genes encoding transforming growth...
    12 KB (1,312 words) - 09:12, 10 September 2024
  • Thumbnail for Paracrine signaling
    the receptors, the phosphorylated receptor complex can activate SMAD2 and SMAD3 through phosphorylation. However, when a BMP ligand binds to the receptors...
    46 KB (4,967 words) - 21:12, 7 July 2024
  • regulate the expression of certain genes. The R-Smads consist of Smad1, Smad2, Smad3, Smad5 and Smad8/9, and are involved in direct signaling from the TGF-B...
    35 KB (4,590 words) - 22:05, 24 August 2024
  • activates the protein. There are five receptor regulated SMADs: SMAD1, SMAD2, SMAD3, SMAD5, and SMAD9 (sometimes referred to as SMAD8). There are essentially...
    20 KB (2,098 words) - 00:36, 28 November 2023
  • Thumbnail for Inflammation
    Weinstein M, Letterio JL, Mizel DE, et al. (September 1999). "Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response"...
    97 KB (9,537 words) - 01:09, 13 September 2024
  • Thumbnail for Craniosynostosis
    dilatation • aneurysms 609192 610168 613795 608967 610380 TGFBR1, TGFBR2, SMAD3 Saethre–Chotzen syndrome facial asymmetry • low frontal hairline • drooping...
    71 KB (7,697 words) - 06:54, 15 April 2024
  • collagen type IV in human vascular smooth muscle cells is regulated by both SMAD3 protein and TGFβ mediated stimulation of mRNA. Altogether, it was concluded...
    21 KB (2,423 words) - 04:24, 10 August 2024
  • Thumbnail for Androgen receptor
    RAD9A, RANBP9, RCHY1, Retinoblastoma protein, RNF14, RNF4, SART3, SIRT1, SMAD3, Small heterodimer partner, Src, SRY, STAT3, SVIL, Testicular receptor 2...
    87 KB (9,376 words) - 13:18, 19 August 2024
  • Thumbnail for Activin and inhibin
    interacts with and then phosphorylates SMAD2 and SMAD3, two of the cytoplasmic SMAD proteins. Smad3 then translocates to the nucleus and interacts with...
    26 KB (2,557 words) - 08:59, 5 August 2024