Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes, EC 1.14.99.1) that...
16 KB (1,779 words) - 11:08, 3 July 2024
Cyclooxygenase-2 (COX-2), also known as Prostaglandin-endoperoxide synthase 2 (HUGO PTGS2), is an enzyme that in humans is encoded by the PTGS2 gene. In...
30 KB (3,417 words) - 14:36, 15 May 2024
Cyclooxygenase 1 (COX-1), also known as prostaglandin-endoperoxide synthase 1 (HUGO PTGS1), is an enzyme that in humans is encoded by the PTGS1 gene. In...
18 KB (2,122 words) - 12:15, 2 June 2024
Cyclooxygenase-3 (COX-3) is an enzyme that is encoded by the PTGS1 (COX1) gene, but is not functional in humans. COX-3 is the third and most recently discovered...
20 KB (2,584 words) - 05:01, 11 May 2024
Cyclooxygenase-2 inhibitors (COX-2 inhibitors), also known as coxibs, are a type of nonsteroidal anti-inflammatory drug (NSAID) that directly target cyclooxygenase-2...
42 KB (4,944 words) - 11:56, 4 April 2024
the third trimester of pregnancy. It blocks cyclooxygenase-2 (COX-2) more than it blocks cyclooxygenase-1 (COX-1). It is in the oxicam family of chemicals...
39 KB (3,755 words) - 15:06, 1 July 2024
thromboxanes is due to its irreversible inactivation of the cyclooxygenase (COX) enzyme. Cyclooxygenase is required for prostaglandin and thromboxane synthesis...
15 KB (1,734 words) - 04:18, 25 March 2024
Nonsteroidal anti-inflammatory drug (redirect from Cyclooxygenase inhibitors)
their introduction in 1948. NSAIDs work by inhibiting the activity of cyclooxygenase enzymes (the COX-1 and COX-2 isoenzymes). In cells, these enzymes are...
110 KB (11,557 words) - 13:31, 18 June 2024
production of prostaglandins by decreasing the activity of the enzyme cyclooxygenase (COX). Ibuprofen is a weaker anti-inflammatory agent than other NSAIDs...
60 KB (5,851 words) - 18:25, 7 July 2024
Prostaglandin (section Cyclooxygenases)
phospholipase-A2, then brought to either the cyclooxygenase pathway or the lipoxygenase pathway. The cyclooxygenase pathway produces thromboxane, prostacyclin...
24 KB (2,463 words) - 17:04, 16 May 2024