Shelterin (also called telosome) is a protein complex known to protect telomeres in many eukaryotes from DNA repair mechanisms, as well as to regulate...

by several proteins, collectively referred to as the shelterin complex. In humans, the shelterin complex consists of six proteins identified as TRF1,...

forming a complex known as shelterin. There are six subunits forming the telomere-binding protein complex known as shelterin: TERF1, TERF2, POT1, TIN2...

length at a rate of approximately 25 nucleotides per year. The telomere-shelterin complexes that cap all eukaryotic chromosomes ensure that healthy cells...

important role in regulating total TERRA expression. Additionally, the Shelterin component TRF1 has been shown to support TERRA transcription. As part...

named shelterin, named for its function of protecting chromosome ends. The six shelterin subunits are: TRF1, TRF2, TIN2, Rap1, TPP1, and POT1. Shelterin subunits...

and is encoded in humans by the TERF2 gene. It is a component of the shelterin nucleoprotein complex and a second negative regulator of telomere length...

TPP1 gene, also known as CLN2. TPP1 should not be confused with the TPP1 shelterin protein which protects telomeres and is encoded by the ACD gene. Mutations...

6-nucleotide sequences that cap the ends of chromosomes. TERRA functions with shelterin to inhibit telomere lengthening by enzyme telomerase. However, other studies...

sequenced. The shelterin protein TPP1 is both necessary and sufficient to recruit the telomerase enzyme to telomeres, and is the only shelterin protein in...