The 1964 United States House of Representatives elections in South Carolina were held on November 3, 1964, to select six Representatives for two-year terms from the state of South Carolina. The primary elections were held on June 9 and the runoff elections were held two weeks later on June 23. All five incumbents who ran were re-elected and the open seat in the 5th congressional district was retained by the Democrats. The composition of the state delegation thus remained solely Democratic.
Incumbent Democratic Congressman Robert T. Ashmore of the 4th congressional district, in office since 1953, won the Democratic primary and was unopposed in the general election.
Incumbent Democratic Congressman Robert W. Hemphill of the 5th congressional district, in office since 1957, opted to retire. Thomas S. Gettys won the Democratic primary and defeated Republican challenger Robert M. Doster in the general election.