3-Oxopentanoic acid
Names | |
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Preferred IUPAC name 3-Oxopentanoic acid | |
Other names β-Ketopentanoate 3-Oxopentanoate 3-Oxovaleric acid 3-Ketovaleric acid | |
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Properties | |
C5H8O3 | |
Molar mass | 116.12 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
3-Oxopentanoic acid, or beta-ketopentanoate, is a 5-carbon ketone body. It is made from odd carbon fatty acids in the liver and rapidly enters the brain.
As opposed to 4-carbon ketone bodies, beta-ketopentanoate is anaplerotic, meaning it can refill the pool of TCA cycle intermediates. The triglyceride triheptanoin is used clinically to produce beta-ketopentanoate.[1]
References
[edit]- ^ Renée P. Kinman; Takhar Kasumov; Kathryn A. Jobbins; Katherine R. Thomas; Jillian Adams; Lisa N. Brunengraber; Gerd Kutz; Wolf-Ulrich Brewer; Charles R. Roe & Henri Brunengraber (2006). "Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats". Am J Physiol Endocrinol Metab. 291 (4): E860–E866. doi:10.1152/ajpendo.00366.2005. PMID 16705058. Reprint