4-Nitrobenzoic acid
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Names | |
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Preferred IUPAC name 4-Nitrobenzoic acid | |
Other names p-Nitrobenzoic acid | |
Identifiers | |
3D model (JSmol) | |
ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.000.479 |
PubChem CID | |
UNII | |
CompTox Dashboard (EPA) | |
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Properties | |
C7H5NO4 | |
Molar mass | 167.1189 g/mol[1] |
Appearance | Light yellow crystalline powder[2] |
Density | 1.58[2] |
Melting point | 237 °C (459 °F; 510 K)[2] |
Boiling point | Sublimes[2] |
<0.1 g/100 mL at 26 °C [3] | |
Acidity (pKa) | 3.41 (in water),[4] 9.1 (in DMSO)[5] |
-78.81·10−6 cm3/mol | |
Related compounds | |
Related compounds | Benzoic acid Nitrobenzene Anthranilic acid 3,5-Dinitrobenzoic acid, 3-Nitrobenzoic acid, 2-Nitrobenzoic acid |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
4-Nitrobenzoic acid is an organic compound with the formula C6H4(NO2)CO2H. It is a pale yellow solid. It is a precursor to 4-nitrobenzoyl chloride, the precursor to the anesthetic procaine and folic acid. It is also a precursor to 4-aminobenzoic acid.[6]
Production
[edit]4-Nitrobenzoic acid is prepared by oxidation of 4-nitrotoluene using oxygen or dichromate as oxidants.[7]
Alternatively, it has been prepared by nitration of polystyrene followed by oxidation of the alkyl substituent. This method proceeds with improved para/ortho selectivity owing to the steric protection of the ortho positions by the polymer backbone.
Safety
[edit]This compound has a rat LD50 of 1960 mg/kg.[8]
References
[edit]- ^ "4-nitrobenzoic acid - PubChem Public Chemical Database". Retrieved 11 April 2010.
- ^ a b c d "Safety data for p-nitrobenzoic acid". Archived from the original on 27 May 2008. Retrieved 11 April 2010.
- ^ "p-Nitrobenzoic acid". Archived from the original on 7 May 2010. Retrieved 11 April 2010.
- ^ "Dissociation Constants Of Organic Acids And Bases". Retrieved 11 April 2010.
- ^ "Bordwell pKa Table (Acidity in DMSO)". Retrieved 11 April 2010.
- ^ Takao Maki; Kazuo Takeda (2002). "Benzoic Acid and Derivatives". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a03_555. ISBN 3527306730..
- ^ O. Kamm; A. O. Matthews (1922). "p-Nitrobenzoic Acid". Org. Synth. 2: 53. doi:10.15227/orgsyn.002.0053.
- ^ "Material Safety Data Sheet - P-nitrobenzoic acid MSDS". Archived from the original on 7 August 2011. Retrieved 11 April 2010.