CDR2 (gene)

CDR2
Identifiers
Aliases	CDR2, CDR62, Yo, cerebellar degeneration related protein 2
External IDs	OMIM: 117340; MGI: 1100885; HomoloGene: 7262; GeneCards: CDR2; OMA:CDR2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	22,437,165 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	120,581,535 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; retinal pigment epithelium; ; jejunal mucosa; ; Epithelium of choroid plexus; ; Achilles tendon; ; sperm; ; cartilage tissue; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; gastric mucosa;
	Top expressed in
	blood; ; fetal liver hematopoietic progenitor cell; ; saccule; ; retinal pigment epithelium; ; tibiofemoral joint; ; otic placode; ; neural layer of retina; ; zygote; ; otic vesicle; ; human fetus;
	More reference expression data
	More reference expression data
Orthologs
	1039
	12585
	ENSG00000140743
	ENSMUSG00000030878
	Q01850
	P97817
	NM_001802
	NM_007672; NM_001354986
	NP_001793
	NP_031698; NP_001341915
	Wikidata
View/Edit Human	View/Edit Mouse

Cerebellar degeneration-related protein 2 is a protein that in humans is encoded by the CDR2 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140743 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030878 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fathallah-Shaykh H, Wolf S, Wong E, Posner JB, Furneaux HM (May 1991). "Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration". Proc Natl Acad Sci U S A. 88 (8): 3451–4. Bibcode:1991PNAS...88.3451F. doi:10.1073/pnas.88.8.3451. PMC 51465. PMID 2014264.
^ "Entrez Gene: CDR2 cerebellar degeneration-related protein 2, 62kDa".

Gress T, Baldini A, Rocchi M, et al. (1992). "In situ mapping of the gene coding for a leucine zipper DNA binding protein (CDR62) to 16p12-16p13.1". Genomics. 13 (4): 1340–2. doi:10.1016/0888-7543(92)90063-X. PMID 1505970.
Sakai K, Mitchell DJ, Tsukamoto T, Steinman L (1992). "Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti-neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration". Ann. Neurol. 30 (5): 738. doi:10.1002/ana.410300523. PMID 1763903.
Sakai K, Mitchell DJ, Tsukamoto T, Steinman L (1991). "Isolation of a complementary DNA clone encoding an autoantigen recognized by an anti-neuronal cell antibody from a patient with paraneoplastic cerebellar degeneration". Ann. Neurol. 28 (5): 692–8. doi:10.1002/ana.410280515. PMID 2260856. S2CID 28532317.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Fletcher CF, Okano HJ, Gilbert DJ, et al. (1998). "Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens". Genomics. 45 (2): 313–9. doi:10.1006/geno.1997.4925. PMID 9344654.
Takanaga H, Mukai H, Shibata H, et al. (1998). "PKN interacts with a paraneoplastic cerebellar degeneration-associated antigen, which is a potential transcription factor". Exp. Cell Res. 241 (2): 363–72. doi:10.1006/excr.1998.4060. PMID 9637778.
Okano HJ, Park WY, Corradi JP, Darnell RB (1999). "The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival". Genes Dev. 13 (16): 2087–97. doi:10.1101/gad.13.16.2087. PMC 316965. PMID 10465786.
Sakai K, Shirakawa T, Li Y, et al. (2002). "Interaction of a paraneoplastic cerebellar degeneration-associated neuronal protein with the nuclear helix-loop-helix leucine zipper protein MRG X.". Mol. Cell. Neurosci. 19 (4): 477–84. doi:10.1006/mcne.2001.1059. PMID 11988016. S2CID 26659745.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sutton IJ, Steele J, Savage CO, et al. (2004). "An interferon-gamma ELISPOT and immunohistochemical investigation of cytotoxic T lymphocyte-mediated tumour immunity in patients with paraneoplastic cerebellar degeneration and anti-Yo antibodies". J. Neuroimmunol. 150 (1–2): 98–106. doi:10.1016/j.jneuroim.2003.12.026. PMID 15081253. S2CID 45697226.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Balbo M, Barel M, Lottin-Divoux S, et al. (2005). "Infection of human B lymphoma cells by Mycoplasma fermentans induces interaction of its elongation factor with the intracytoplasmic domain of Epstein-Barr virus receptor (gp140, EBV/C3dR, CR2, CD21)". FEMS Microbiol. Lett. 249 (2): 359–66. doi:10.1016/j.femsle.2005.06.052. PMID 16054780.

External links

CDR2 human gene location in the UCSC Genome Browser.
CDR2 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140743 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030878 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2014264-5] Fathallah-Shaykh H, Wolf S, Wong E, Posner JB, Furneaux HM (May 1991). "Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration". Proc Natl Acad Sci U S A. 88 (8): 3451–4. Bibcode:1991PNAS...88.3451F. doi:10.1073/pnas.88.8.3451. PMC 51465. PMID 2014264.

[entrez-6] "Entrez Gene: CDR2 cerebellar degeneration-related protein 2, 62kDa".

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[6]

CDR2 (gene)

See also

References

Further reading

External links