Contactin 6

CNTN6
Identifiers
Aliases	CNTN6, contactin 6, NB3
External IDs	OMIM: 607220; MGI: 1858223; HomoloGene: 8702; GeneCards: CNTN6; OMA:CNTN6 - orthologs
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	104,863,406 bp
Gene ontology
Molecular function	Notch binding; cell-cell adhesion mediator activity;
Cellular component	anchored component of membrane; plasma membrane; membrane; parallel fiber to Purkinje cell synapse; anchored component of presynaptic membrane; axon;
Biological process	Notch signaling pathway; central nervous system development; neurogenesis; cell adhesion; nervous system development; neuron differentiation; positive regulation of Notch signaling pathway; homophilic cell adhesion via plasma membrane adhesion molecules; axon guidance; dendrite self-avoidance;
	Sources:Amigo / QuickGO
Orthologs
	27255
	53870
	ENSG00000134115
	ENSMUSG00000030092
	Q9UQ52
	Q9JMB8
	NM_001289080; NM_001289081; NM_014461
	NM_017383
NP_001276009; NP_001276010; NP_055276; NP_001336279; NP_001336280;
	NP_001336281; NP_001336282; NP_001336283; NP_001336284; NP_001336285; NP_001336286; NP_001336287; NP_001336288; NP_001336289; NP_001336290; NP_001336291
	NP_059079
	Wikidata
View/Edit Human	View/Edit Mouse

Contactin 6 is a protein in humans that is encoded by the CNTN6 gene.^[4]

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system.

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030092 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Contactin 6".

Manderson EN, Birch AH, Shen Z, Mes-Masson AM, Provencher D, Tonin PN (May 2009). "Molecular genetic analysis of a cell adhesion molecule with homology to L1CAM, contactin 6, and contactin 4 candidate chromosome 3p26pter tumor suppressor genes in ovarian cancer". International Journal of Gynecological Cancer. 19 (4): 513–25. doi:10.1111/IGC.0b013e3181a3cd38. PMID 19509545. S2CID 27315616.
Wang K, Zhang H, Bloss CS, Duvvuri V, Kaye W, Schork NJ, Berrettini W, Hakonarson H (September 2011). "A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa" (PDF). Molecular Psychiatry. 16 (9): 949–59. doi:10.1038/mp.2010.107. PMC 3859494. PMID 21079607.
Barber MJ, Mangravite LM, Hyde CL, Chasman DI, Smith JD, McCarty CA, Li X, Wilke RA, Rieder MJ, Williams PT, Ridker PM, Chatterjee A, Rotter JI, Nickerson DA, Stephens M, Krauss RM (March 2010). Zanger U (ed.). "Genome-wide association of lipid-lowering response to statins in combined study populations". PLOS ONE. 5 (3): e9763. Bibcode:2010PLoSO...5.9763B. doi:10.1371/journal.pone.0009763. PMC 2842298. PMID 20339536.
Kamei Y, Tsutsumi O, Taketani Y, Watanabe K (February 1998). "cDNA cloning and chromosomal localization of neural adhesion molecule NB-3 in human". Journal of Neuroscience Research. 51 (3): 275–83. doi:10.1002/(SICI)1097-4547(19980201)51:3<275::AID-JNR1>3.0.CO;2-D. PMID 9486763. S2CID 43122787.
Walsh FS, Doherty P (November 1991). "Glycosylphosphatidylinositol anchored recognition molecules that function in axonal fasciculation, growth and guidance in the nervous system". Cell Biology International Reports. 15 (11): 1151–66. doi:10.1016/0309-1651(91)90061-M. PMID 1838307.
Nie DY, Zhou ZH, Ang BT, Teng FY, Xu G, Xiang T, Wang CY, Zeng L, Takeda Y, Xu TL, Ng YK, Faivre-Sarrailh C, Popko B, Ling EA, Schachner M, Watanabe K, Pallen CJ, Tang BL, Xiao ZC (November 2003). "Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K(+) channel localization". The EMBO Journal. 22 (21): 5666–78. doi:10.1093/emboj/cdg570. PMC 275427. PMID 14592966.
Saus E, Brunet A, Armengol L, Alonso P, Crespo JM, Fernández-Aranda F, Guitart M, Martín-Santos R, Menchón JM, Navinés R, Soria V, Torrens M, Urretavizcaya M, Vallès V, Gratacòs M, Estivill X (October 2010). "Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients". Journal of Psychiatric Research. 44 (14): 971–8. doi:10.1016/j.jpsychires.2010.03.007. PMID 20398908.^{[permanent dead link‍]}

External links

Overview of all the structural information available in the PDB for UniProt: Q9JMB8 (Contactin-6) at the PDBe-KB.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000030092 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: Contactin 6".

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[2]

[3]

[4]

Contactin 6

References

Further reading

External links