CNTRL

CNTRL
Identifiers
Aliases	CNTRL, CEP1, CEP110, FAN, bA165P4.1, centriolin
External IDs	OMIM: 605496; MGI: 1889576; HomoloGene: 38260; GeneCards: CNTRL; OMA:CNTRL - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	121,177,729 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	35,178,822 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; secondary oocyte; ; ventricular zone; ; bronchial epithelial cell; ; testicle; ; left testis; ; right testis; ; sural nerve; ; sperm; ; monocyte;
	Top expressed in
	genital tubercle; ; ventricular zone; ; granulocyte; ; spermatocyte; ; tail of embryo; ; thymus; ; mesenteric lymph nodes; ; spermatid; ; spleen; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein tyrosine kinase activity; cytoskeletal protein binding;
Cellular component	microtubule organizing center; centrosome; cytoskeleton; membrane; cytoplasm; cytosol; midbody; Flemming body; centriolar subdistal appendage;
Biological process	cell division; cell cycle; G2/M transition of mitotic cell cycle; peptidyl-tyrosine phosphorylation; mitotic cell cycle; ciliary basal body-plasma membrane docking; regulation of G2/M transition of mitotic cell cycle; regulation of cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	11064
	26920
	ENSG00000119397
	ENSMUSG00000057110
	Q7Z7A1
	A2AL36
NM_007018; NM_001330762; NM_001369892; NM_001369893; NM_001369894;
	NM_001369895; NM_001369896
	NM_001290635; NM_012018; NM_030000; NM_001379274; NM_001379275
NP_001317691; NP_008949; NP_001356821; NP_001356822; NP_001356823;
	NP_001356824; NP_001356825
	NP_001277564; NP_036148; NP_001366203; NP_001366204
	Wikidata
View/Edit Human	View/Edit Mouse

Centriolin is a protein that in humans is encoded by the CNTRL gene. It was previously known as CEP110.^[5]^[6]

This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centriolin.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119397 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057110 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Guasch G, Mack GJ, Popovici C, Dastugue N, Birnbaum D, Rattner JB, Pebusque MJ (Mar 2000). "FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)". Blood. 95 (5): 1788–96. doi:10.1182/blood.V95.5.1788.005k15_1788_1796. PMID 10688839.
^ ^a ^b "Entrez Gene: CEP110 centrosomal protein 110kDa".

External links

Human CNTRL genome location and CNTRL gene details page in the UCSC Genome Browser.

Gromley A, Yeaman C, Rosa J, et al. (2005). "Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission". Cell. 123 (1): 75–87. doi:10.1016/j.cell.2005.07.027. PMID 16213214. S2CID 6665005.
Guinn BA, Bland EA, Lodi U, et al. (2005). "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia". Biochem. Biophys. Res. Commun. 335 (4): 1293–304. doi:10.1016/j.bbrc.2005.08.024. PMID 16112646.
Jurczyk A, Gromley A, Redick S, et al. (2004). "Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly". J. Cell Biol. 166 (5): 637–43. doi:10.1083/jcb.200405023. PMC 2172416. PMID 15337773.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gromley A, Jurczyk A, Sillibourne J, et al. (2003). "A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase". J. Cell Biol. 161 (3): 535–45. doi:10.1083/jcb.200301105. PMC 2172935. PMID 12732615.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ou YY, Mack GJ, Zhang M, Rattner JB (2002). "CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation". J. Cell Sci. 115 (Pt 9): 1825–35. doi:10.1242/jcs.115.9.1825. PMID 11956314.
Popovici C, Mattéi MG, Rattner JB, et al. (2000). "Assignment of the centrosomal protein 110 gene (Cep110) to mouse chromosome bands 2B-C1 by in situ hybridization". Cytogenet. Cell Genet. 89 (3–4): 216–7. doi:10.1159/000015616. PMID 10965126. S2CID 31717030.
Osaki E, Nishina Y, Inazawa J, et al. (1999). "Identification of a novel Sry-related gene and its germ cell-specific expression". Nucleic Acids Res. 27 (12): 2503–10. doi:10.1093/nar/27.12.2503. PMC 148454. PMID 10359848.
Schütze S, Machleidt T, Adam D, et al. (1999). "Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling". J. Biol. Chem. 274 (15): 10203–12. doi:10.1074/jbc.274.15.10203. PMID 10187805.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119397 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057110 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10688839-5] Guasch G, Mack GJ, Popovici C, Dastugue N, Birnbaum D, Rattner JB, Pebusque MJ (Mar 2000). "FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)". Blood. 95 (5): 1788–96. doi:10.1182/blood.V95.5.1788.005k15_1788_1796. PMID 10688839.

[entrez-6] "Entrez Gene: CEP110 centrosomal protein 110kDa".

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[6]

v t e The centrosome and its components
Centrioles	SASS6 CENPJ CNTROB CEP104 Centrins (CETN1, CETN2 and CETN3) SFI1
Pericentriolar material	BBS4 Lck PCM1 PCNT TNKS TNKS2 TUBE1
other proteins	CCP110 CEP55 CEP57 CEP63 CEP68 CEP70 CEP72 CEP76 CEP78 CEP90 CEP97 CEP120 CEP135 CEP152 CEP164 CEP170 CEP192 CEP215 CEP250 CEP350 CNTRL NIN NINL

CNTRL

References

External links

Further reading