Protein-coding gene in humans
COP9 signalosome complex subunit 8 is a protein that in humans is encoded by the COPS8 gene .[ 5] [ 6] [ 7]
The protein encoded by this gene is the smallest of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is related to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[ 7]
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S2CID 11639677 . ^ a b "Entrez Gene: COPS8 COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)" . Schwechheimer C, Deng XW (2001). "COP9 signalosome revisited: a novel mediator of protein degradation". Trends Cell Biol . 11 (10): 420–6. doi :10.1016/S0962-8924(01)02091-8 . PMID 11567875 . Wolf DA, Zhou C, Wee S (2004). "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol . 5 (12): 1029–33. doi :10.1038/ncb1203-1029 . PMID 14647295 . S2CID 37458780 . Chamovitz DA, Wei N, Osterlund MT, Von Arnim AG, Staub JM, Matsui M, et al. (1996). "The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch" . Cell . 86 (1): 115–21. doi :10.1016/S0092-8674(00)80082-3 PMID 8689678 . Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags" . Genome Res . 6 (9): 807–28. doi :10.1101/gr.6.9.807 PMID 8889549 . Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, et al. (1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits" . FASEB J . 12 (6): 469–78. doi :10.1096/fasebj.12.6.469 PMID 9535219 . S2CID 25424324 . Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, et al. (1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex" . Curr. Biol . 8 (16): 919–22. Bibcode :1998CBio....8..919W . doi :10.1016/S0960-9822(07)00372-7 PMID 9707402 . S2CID 13873982 . Naumann M, Bech-Otschir D, Huang X, Ferrell K, Dubiel W (2000). "COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK" . J. Biol. Chem . 274 (50): 35297–300. doi :10.1074/jbc.274.50.35297 PMID 10585392 . Cohen H, Azriel A, Cohen T, Meraro D, Hashmueli S, Bech-Otschir D, et al. (2001). "Interaction between Interferon Consensus Sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome" . J. Biol. Chem . 275 (50): 39081–9. doi :10.1074/jbc.M004900200 PMID 10991940 . Gizatullin RZ, Muravenko OV, Al-Amin AN, Wang F, Protopopov AI, Kashuba VI, et al. (2001). "Human COP9 subunit 8 homolog gene SGN8 Map position 2q37". Chromosome Res . 8 (6): 559. doi :10.1023/A:1009279908306 . PMID 11032325 . S2CID 12957157 . Bech-Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C, et al. (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system" . EMBO J . 20 (7): 1630–9. doi :10.1093/emboj/20.7.1630 . PMC 145508 PMID 11285227 . Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science . 292 (5520): 1382–5. Bibcode :2001Sci...292.1382L . doi :10.1126/science.1059780 . PMID 11337588 . S2CID 14224920 . Hoareau Alves K, Bochard V, Réty S, Jalinot P (2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome" . FEBS Lett . 527 (1–3): 15–21. doi :10.1016/S0014-5793(02)03147-2 PMID 12220626 . S2CID 39308598 . Sun Y, Wilson MP, Majerus PW (2003). "Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1" . J. Biol. Chem . 277 (48): 45759–64. doi :10.1074/jbc.M208709200 PMID 12324474 . Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Serino G, Su H, Peng Z, Tsuge T, Wei N, Gu H, et al. (2003). "Characterization of the Last Subunit of the Arabidopsis COP9 Signalosome: Implications for the Overall Structure and Origin of the Complex" . Plant Cell . 15 (3): 719–31. doi :10.1105/tpc.009092 . PMC 150025 PMID 12615944 . Uhle S, Medalia O, Waldron R, Dumdey R, Henklein P, Bech-Otschir D, et al. (2003). "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome" . EMBO J . 22 (6): 1302–12. doi :10.1093/emboj/cdg127 . PMC 151059 PMID 12628923 .
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