Capravirine

Capravirine
Names
	Preferred IUPAC name {5-[(3,5-Dichlorophenyl)sulfanyl]-4-(propan-2-yl)-1-[(pyridin-4-yl)methyl]-1H-imidazol-2-yl}methyl carbamate
Identifiers
CAS Number	178979-85-6 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL435128 ;
ChemSpider	1717 ;
PubChem CID	1783;
UNII	VHC779598X ;
CompTox Dashboard (EPA)	DTXSID30170689 ;
	InChI InChI=1S/C20H20Cl2N4O2S/c1-12(2)18-19(29-16-8-14(21)7-15(22)9-16)26(10-13-3-5-24-6-4-13)17(25-18)11-28-20(23)27/h3-9,12H,10-11H2,1-2H3,(H2,23,27) Key: YQXCVAGCMNFUMQ-UHFFFAOYSA-N ; InChI=1/C20H20Cl2N4O2S/c1-12(2)18-19(29-16-8-14(21)7-15(22)9-16)26(10-13-3-5-24-6-4-13)17(25-18)11-28-20(23)27/h3-9,12H,10-11H2,1-2H3,(H2,23,27) Key: YQXCVAGCMNFUMQ-UHFFFAOYAP;
	SMILES O=C(OCc2nc(c(Sc1cc(Cl)cc(Cl)c1)n2Cc3ccncc3)C(C)C)N;
Properties
Chemical formula	C20H20Cl2N4O2S
Molar mass	451.37 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Capravirine was a non-nucleoside reverse transcriptase inhibitor which reached phase II trials before development was discontinued by Pfizer.^[1]^[2] Both phase IIb trials which were conducted failed to demonstrate that therapy with capravirine provided any significant advantage over existing triple-drug HIV therapies, and pharmacology studies showed that capravirine may interact with other HIV drugs.^[3]^[4]

References

^ PubChem. "Capravirine". pubchem.ncbi.nlm.nih.gov. Retrieved 2019-06-02.
^ "Capravirine - Anti-Retroviral Drug". Drug Development Technology. Retrieved 2019-06-02.
^ "Capravirine - Anti-Retroviral Drug". Drug Development Technology. Retrieved 2019-06-02.
^ "A Study of Capravirine Plus VIRACEPT Plus Two Nucleoside Reverse Transcriptase Inhibitors in HIV-Infected Patients Who Failed Previous Anti-HIV Treatments - Full Text View - ClinicalTrials.gov". clinicaltrials.gov. 23 June 2005. Retrieved 2019-06-02.

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[1] PubChem. "Capravirine". pubchem.ncbi.nlm.nih.gov. Retrieved 2019-06-02.

[2] "Capravirine - Anti-Retroviral Drug". Drug Development Technology. Retrieved 2019-06-02.

[3] "Capravirine - Anti-Retroviral Drug". Drug Development Technology. Retrieved 2019-06-02.

[4] "A Study of Capravirine Plus VIRACEPT Plus Two Nucleoside Reverse Transcriptase Inhibitors in HIV-Infected Patients Who Failed Previous Anti-HIV Treatments - Full Text View - ClinicalTrials.gov". clinicaltrials.gov. 23 June 2005. Retrieved 2019-06-02.

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Names

Preferred IUPAC name {5-[(3,5-Dichlorophenyl)sulfanyl]-4-(propan-2-yl)-1-[(pyridin-4-yl)methyl]-1H-imidazol-2-yl}methyl carbamate
Identifiers
CAS Number	178979-85-6^Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL435128^N
ChemSpider	1717^N
PubChem CID	1783
UNII	VHC779598X^N
CompTox Dashboard (EPA)	DTXSID30170689
InChI InChI=1S/C20H20Cl2N4O2S/c1-12(2)18-19(29-16-8-14(21)7-15(22)9-16)26(10-13-3-5-24-6-4-13)17(25-18)11-28-20(23)27/h3-9,12H,10-11H2,1-2H3,(H2,23,27)^N Key: YQXCVAGCMNFUMQ-UHFFFAOYSA-N^N InChI=1/C20H20Cl2N4O2S/c1-12(2)18-19(29-16-8-14(21)7-15(22)9-16)26(10-13-3-5-24-6-4-13)17(25-18)11-28-20(23)27/h3-9,12H,10-11H2,1-2H3,(H2,23,27) Key: YQXCVAGCMNFUMQ-UHFFFAOYAP
SMILES O=C(OCc2nc(c(Sc1cc(Cl)cc(Cl)c1)n2Cc3ccncc3)C(C)C)N
Properties
Chemical formula	C₂₀H₂₀Cl₂N₄O₂S
Molar mass	451.37 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references