Cefacetrile
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Clinical data | |
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Trade names | Celospor, Celtol, Cristacef |
AHFS/Drugs.com | International Drug Names |
Routes of administration | Intravenous, intramuscular, intramammary |
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Pharmacokinetic data | |
Protein binding | 23 to 38% |
Elimination half-life | 1.2 hours |
Excretion | Renal (72%) |
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ECHA InfoCard | 100.030.449 |
Chemical and physical data | |
Formula | C13H13N3O6S |
Molar mass | 339.32 g·mol−1 |
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Cefacetrile (INN, also spelled cephacetrile) is a broad-spectrum first generation cephalosporin antibiotic effective in gram-positive and gram-negative bacterial infections. It is a bacteriostatic antibiotic.[1][2] Cefacetrile is marketed under the trade names Celospor, Celtol, and Cristacef,[3] and as Vetimast for the treatment of mammary infections in lactating cows.[2]
Synthesis
[edit]![](http://upload.wikimedia.org/wikipedia/commons/thumb/4/4f/Cefacetrile_synthesis.svg/500px-Cefacetrile_synthesis.svg.png)
It was made by reacting 7-ACA (7-aminocephalosporanic acid) with cyanoacetyl chloride in the presence of tributylamine.[citation needed]
References
[edit]- ^ "Cefacetrile Summary Report" (PDF). European Medicines Agency, Committee for Veterinary Medicinal Products. 1998. Archived from the original (PDF) on 2020-05-26. Retrieved 2012-01-25.
- ^ a b Haberfeld H, ed. (2007). Austria-Codex (in German) (2007/2008 ed.). Vienna: Österreichischer Apothekerverlag. ISBN 978-3-85200-183-8.
- ^ Horiuchi N, Oyakawa Y, Oka R, Fujiwara T (October 1980). "[Clinical evaluation of cephacetrile (Celtol) for respiratory infections (author's transl)]". The Japanese Journal of Antibiotics. 33 (10): 1145–55. PMID 7206219.