Corynebacterium glutamicum

Corynebacterium glutamicum
C. glutamicum under scanning electron microscopy.
Scientific classification Edit this classification
Domain: Bacteria
Phylum: Actinomycetota
Class: Actinomycetia
Order: Mycobacteriales
Family: Corynebacteriaceae
Genus: Corynebacterium
Species:
C. glutamicum
Binomial name
Corynebacterium glutamicum
(Kinoshita et al. 1958) Abe et al. 1967 (Approved Lists 1980)
Synonyms[1][2]
  • Brevibacterium divaricatum Su and Yamada 1960 (Approved Lists 1980)
  • "Brevibacterium flavum" Okumura et al. 1962
  • Corynebacterium lilium Lee and Good 1963 (Approved Lists 1980)
  • "Micrococcus glutamicus" Kinoshita et al. 1958

Corynebacterium glutamicum is a Gram-positive, rod-shaped bacterium that is used industrially for large-scale production of amino acids,[3][4] especially glutamic acid and lysine.[5] While originally identified in a screen for organisms secreting L-glutamate, mutants of C. glutamicum have also been identified that produce various other amino acids and derivatives of amino acids.[6]

Due to its industrial importance, several clones of C. glutamicum have been sequenced by both industry and academic groups.[5] Furthermore, small RNA data was obtained by RNA-Seq in C. glutamicum ATCC 13032.[7] The metabolism of this strain has been reconstructed and is available in the form of a genome-scale metabolic model.[8]

See also

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References

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  1. ^ Tatsumi, Nami; Inui, Masayuki (14 August 2012). Corynebacterium glutamicum: Biology and Biotechnology. Springer Science & Business Media. p. 336. ISBN 978-3-642-29857-8.
  2. ^ Lv, Yangyong; Juanjun, Liao; Wu, Zhanhong; et al. (February 2012). "Genome Sequence of Corynebacterium glutamicum ATCC 14067, Which Provides Insight into Amino Acid Biosynthesis in Coryneform Bacteria". Journal of Bacteriology. 194 (3): 742–743. doi:10.1128/JB.06514-11. PMC 3264075. PMID 22247536.
  3. ^ Kinoshita, Shukuo; Udaka, Shigezo; Shimono, Masakazu (1957), "Studies on the amino acid fermentation. Part 1. Production of L-glutamic acid by various microorganisms", Journal of General and Applied Microbiology, 3 (3): 193–205, doi:10.2323/jgam.3.193, PMID 15965888{{citation}}: CS1 maint: multiple names: authors list (link)
  4. ^ Udaka, Shigezo (1960), "Screening method for microorganisms accumulating metabolites and its use in the isolation of Micrococcus glutamicus", Journal of Bacteriology, 79 (5): 754–755, doi:10.1128/jb.79.5.754-755.1960, PMC 278770, PMID 13840150
  5. ^ a b Kalinowski, J; Bathe, B; Bartels, D; et al. (4 September 2003). "The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of l-aspartate-derived amino acids and vitamins". Journal of Biotechnology. 104 (1–3): 5–25. doi:10.1016/S0168-1656(03)00154-8. PMID 12948626.
  6. ^ Zahoor A; Lindner SN; Wendisch VF (October 2012). "Metabolic Engineering of Corynebacterium glutamicum Aimed at Alternative Carbon Sources and New Products". Computational and Structural Biotechnology Journal. 3 (4): e201210004. doi:10.5936/csbj.201210004. PMC 3962153. PMID 24688664.
  7. ^ Mentz, Almut; Neshat, Armin; Pfeifer-Sancar, Katharina; et al. (2013-10-19). "Comprehensive discovery and characterization of small RNAs in Corynebacterium glutamicum ATCC 13032". BMC Genomics. 14 (1): 714. doi:10.1186/1471-2164-14-714. ISSN 1471-2164. PMC 4046766. PMID 24138339.
  8. ^ Feierabend, Martina; Renz, Alina; Zelle, Elisabeth; et al. (2021). "High-Quality Genome-Scale Reconstruction of Corynebacterium glutamicum ATCC 13032". Frontiers in Microbiology. 12 (10): 3432. doi:10.3389/fmicb.2021.750206. ISSN 1664-302X. PMC 8634658. PMID 34867870.
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