Cyclin B2

CCNB2
Identifiers
AliasesCCNB2, HsT17299, Cyclin B2
External IDsOMIM: 602755; MGI: 88311; HomoloGene: 74359; GeneCards: CCNB2; OMA:CCNB2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004701

NM_007630

RefSeq (protein)

NP_004692

NP_031656

Location (UCSC)Chr 15: 59.11 – 59.13 MbChr 9: 70.31 – 70.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene.

Function

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Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.[5]

Interactions

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Cyclin B2 has been shown to interact with TGF beta receptor 2.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157456Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032218Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CCNB2 cyclin B2".
  6. ^ Liu JH, Wei S, Burnette PK, Gamero AM, Hutton M, Djeu JY (Jan 1999). "Functional association of TGF-beta receptor II with cyclin B". Oncogene. 18 (1): 269–75. doi:10.1038/sj.onc.1202263. PMID 9926943.

Further reading

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