Elizabeth A. Winzeler
Elizabeth Ann Winzeler | |
---|---|
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Born | |
Citizenship | USA |
Education | |
Known for | Microbial genetics and genomics, drug design, drug resistance |
Scientific career | |
Fields | microbiology molecular biology parasitology genetics drug discovery |
Institutions | University of California, San Diego |
Thesis | Transcriptional analysis of the Caulobacter 4.5 S RNA ffs gene and the physiological basis of an ffs mutant with a ts phenotype (1996) |
Doctoral advisor | Lucy Shapiro |
Other academic advisors | Ronald W. Davis |
Website | winzeler |
Elizabeth Ann Winzeler is an American microbiologist and geneticist. She is a professor in the Division of Host-Microbe Systems and Therapeutics of the School of Medicine at the University of California at San Diego.[1] Although she works in a variety of different disease areas, most research focuses on developing better medicines for the treatment and eradication of malaria.
Early life and education
[edit]Winzeler is the daughter of anthropologist, Robert L. Winzeler. She grew up in Reno, Nevada, and attended Lewis and Clark College in Portland, Oregon.[2] She received her B.A. in Natural Sciences and Art in 1984.[2][3] After college, she worked as a professional programmer and systems analyst[2] for four years before moving to Oregon State University in Corvallis, Oregon[2] to earn a M.S. in Biophysics and Biochemistry. In 1996, she was awarded a Ph.D. from Stanford University in Developmental Biology[2] for her studies on Caulobacter crescentus with Lucy Shapiro. She stayed at Stanford for postdoctoral work with Ronald W. Davis. At Stanford she played a leading role in developing seminal post-genome analysis methods in Saccharomyces cerevisiae.[4][5]
Career
[edit]In 1999, Winzeler was recruited by Peter G. Schultz to the newly established Genomics Institute of the Novartis Research Foundation. In 2000, she obtained a secondary position as an assistant professor in the Department of Cell Biology at Scripps Research. In 2012, she moved to the University of California, San Diego where she is currently a professor in the Department of Pediatrics and director of Translational Research at the UCSD Health Sciences Center for Immunity, Infection, and Inflammation.[2] She is a member of the Division of Host Microbe Systems and Therapeutics and the Institute for Genomic Medicine.
![](http://upload.wikimedia.org/wikipedia/commons/thumb/e/e6/Malaria_parasite_life_cycle-NIAID.jpg/220px-Malaria_parasite_life_cycle-NIAID.jpg)
Research
[edit]While she was still at Stanford University, she began working at the interface of genetics and informatics in the new field of functional genomics.[5] After establishing her own lab, she began applying the powerful, high throughput methods that worked well in yeast to organisms that were both more medically relevant and experimentally-challenging, namely the protozoan Plasmodium parasites that cause human malaria. She showed that malaria parasites produce coordinated sets of gene messages as they progress through their complex lifecycle[6] and developed methods for studying parasite genetic variation and genome evolution especially in relationship to the emergence of drug resistance.[2][7][8] She is also known for developing phenotypic screening methods[9] as well as contributions to drug development and Open Source Drug Discovery.[10][11] Her group has developed screening methods that have led to the discovery of several new antimalarial chemotypes, two of which have been developed into clinical candidates. These include Ganaplacide (KAF156)[12] and Cipargamin (KAE609).[13][14] In addition, her lab discovered the targets of a variety of antimalarial compounds, including PfATP4,[14] and Pf1-phosphatidylinositol 4-kinase.[15] In 2017 she became director of the Bill and Melinda Gates Foundation Malaria Drug Accelerator (MALDA),[16] an international consortium that seeks to develop better treatments for malaria. She is a member of the governing board of the Tres Cantos Open Lab Foundation.
Awards and honors
[edit]- Ellison Medical Foundation New Scholar in Global Infectious Disease[17] 2001
- W. M. Keck Foundation New Scholar Award[18] 2004
- Howard T. Ricketts[19] Symposium Lecture 2013
- Bailey K. Ashford Medal[20] American Society of Tropical Medicine and Hygiene (ASTMH) 2014
- Fellow, American Academy of Microbiology[21] 2016
- Medicines for Malaria Venture Project of the Year[22] 2017
- Alice and C. C. Wang in Molecular Parasitology[23] 2018
- William Trager Award on behalf of ASTMH and the American Committee of Molecular, Cellular and Immunoparasitology[24] 2018
- Ruth Sonntag Nussenzweig Memorial Symposium 2019
- United Arab Emirates Crown Prince, Reaching the Last Mile Finalist[25] 2019
- Rady Children's Hospital Awards of Excellence in Basic Research 2020
- UCSD Health Science Women Leadership Award 2020
- Elected to the National Academy of Medicine [1][26] 2021
References
[edit]- ^ Tom Vasich, Scott LaFee, Niall Kavanagh (April 28, 2017). Tackling malaria worldwide. The Regents of the University of California. Accessed October 2018.
- ^ a b c d e f g Valo, Ellisa (January 24, 2017). "Ending Malaria". Lewis and Clark College. Retrieved October 27, 2018.
- ^ Elizabeth, Winzeler (Jan 11, 2019). "An improbable journey: Creativity helped me make the transition from art to curing malaria". J Biol Chem. 294 (2): 405–409. doi:10.1074/jbc.AW118.005229. PMC 6333892. PMID 30401750.
- ^ "Behind the Scenes". New Scientist. August 14, 1999. Retrieved October 27, 2018.
- ^ a b Winzeler, EA; Shoemaker, DD; Astromoff, A; Liang, H; Anderson, K; Andre, B; Bangham, R; Benito, R; Boeke, JD; Bussey, H; Chu, AM; Connelly, C; Davis, K; Dietrich, F; Dow, SW; El Bakkoury, M; Foury, F; Friend, SH; Gentalen, E; Giaever, G; Hegemann, JH; Jones, T; Laub, M; Liao, H; Liebundguth, N; Lockhart, DJ; Lucau-Danila, A; Lussier, M; M'Rabet, N; Menard, P; Mittmann, M; Pai, C; Rebischung, C; Revuelta, JL; Riles, L; Roberts, CJ; Ross-MacDonald, P; Scherens, B; Snyder, M; Sookhai-Mahadeo, S; Storms, RK; Véronneau, S; Voet, M; Volckaert, G; Ward, TR; Wysocki, R; Yen, GS; Yu, K; Zimmermann, K; Philippsen, P; Johnston, M; Davis, RW (6 August 1999). "Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis". Science. 285 (5429): 901–6. doi:10.1126/science.285.5429.901. PMID 10436161.
- ^ Le Roch, K. G; Zhou, Y; Blair, P. L; Grainger, M; Moch, J. K; Haynes, J. D; de la Vega, P; Holder, A. A; Batalov, S; Carucci, D. J; Winzeler, E. A (2003). "Discovery of gene function by expression profiling of the malaria parasite life cycle". Science. 301(5639): 1503–8. Bibcode:2003Sci...301.1503L. doi:10.1126/science.1087025. PMID12893887.
- ^ Zhou, Y; Ramachandran, V; Kumar, K. A; Westenberger, S; Refour, P; Zhou, B; Li, F; Young, J. A; Chen, K; Plouffe, D; Henson, K; Nussenzweig, V; Carlton, J; Vinetz, J. M; Duraisingh, M. T; Winzeler, E. A (2008). "Evidence-based annotation of the malaria parasite's genome using comparative expression profiling". Public Library Of Science ONE. 3(2): e1570. Bibcode:2008PLoSO...3.1570Z. doi:10.1371/journal.pone.0001570. PMC2215772. PMID18270564.
- ^ Young, J. A; Fivelman, Q. L; Blair, P. L; de la Vega, P; Le Roch, K. G; Zhou, Y; Carucci, D. J; Baker, D. A; Winzeler, E. A (2005). "The Plasmodium falciparum sexual development transcriptome: A microarray analysis using ontology-based pattern identification" (PDF). Molecular and Biochemical Parasitology. 143(1): 67–79. doi:10.1016/j.molbiopara.2005.05.007. PMID16005087.
- ^ Plouffe, D. M; Wree, M; Du, A. Y; Meister, S; Li, F; Patra, K; Lubar, A; Okitsu, S. L; Flannery, E. L; Kato, N; Tanaseichuk, O; Comer, E; Zhou, B; Kuhen, K; Zhou, Y; Leroy, D; Schreiber, S. L; Scherer, C. A; Vinetz, J; Winzeler, E. A (2016). "High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission". Cell Host & Microbe. 19(1): 114–26. doi:10.1016/j.chom.2015.12.001. PMC4723716. PMID26749441.
- ^ Meister, S; Plouffe, DM; Kuhen, KL; Bonamy, GM; Wu, T; Barnes, SW; Bopp, SE; Borboa, R; Bright, AT; Che, J; Cohen, S; Dharia, NV; Gagaring, K; Gettayacamin, M; Gordon, P; Groessl, T; Kato, N; Lee, MC; McNamara, CW; Fidock, DA; Nagle, A; Nam, TG; Richmond, W; Roland, J; Rottmann, M; Zhou, B; Froissard, P; Glynne, RJ; Mazier, D; Sattabongkot, J; Schultz, PG; Tuntland, T; Walker, JR; Zhou, Y; Chatterjee, A; Diagana, TT; Winzeler, EA (9 December 2011). "Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery". Science. 334 (6061): 1372–7. Bibcode:2011Sci...334.1372M. doi:10.1126/science.1211936. PMC 3473092. PMID 22096101.
- ^ Antonova-Koch, Y; Meister, S; Abraham, M; Luth, MR; Ottilie, S; Lukens, AK; Sakata-Kato, T; Vanaerschot, M; Owen, E; Jado, JC; Maher, SP; Calla, J; Plouffe, D; Zhong, Y; Chen, K; Chaumeau, V; Conway, AJ; McNamara, CW; Ibanez, M; Gagaring, K; Serrano, FN; Eribez, K; Taggard, CM; Cheung, AL; Lincoln, C; Ambachew, B; Rouillier, M; Siegel, D; Nosten, F; Kyle, DE; Gamo, FJ; Zhou, Y; Llinás, M; Fidock, DA; Wirth, DF; Burrows, J; Campo, B; Winzeler, EA (7 December 2018). "Open-source discovery of chemical leads for next-generation chemoprotective antimalarials". Science. 362 (6419): eaat9446. Bibcode:2018Sci...362.9446A. doi:10.1126/science.aat9446. PMC 6516198. PMID 30523084.
- ^ Kuhen, K. L; Chatterjee, A. K; Rottmann, M; Gagaring, K; Borboa, R; Buenviaje, J; Chen, Z; Francek, C; Wu, T; Nagle, A; Barnes, S. W; Plouffe, D; Lee, M. C; Fidock, D. A; Graumans, W; Van De Vegte-Bolmer, M; Van Gemert, G. J; Wirjanata, G; Sebayang, B; Marfurt, J; Russell, B; Suwanarusk, R; Price, R. N; Nosten, F; Tungtaeng, A; Gettayacamin, M; Sattabongkot, J; Taylor, J; Walker, J. R; et al. (2014). "KAF156 is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission". Antimicrobial Agents and Chemotherapy. 58(9): 5060–5067. doi:10.1128/AAC.02727-13. PMC4135840. PMID24913172.
- ^ Yeung, BK; Zou, B; Rottmann, M; Lakshminarayana, SB; Ang, SH; Leong, SY; Tan, J; Wong, J; Keller-Maerki, S; Fischli, C; Goh, A; Schmitt, EK; Krastel, P; Francotte, E; Kuhen, K; Plouffe, D; Henson, K; Wagner, T; Winzeler, EA; Petersen, F; Brun, R; Dartois, V; Diagana, TT; Keller, TH (22 July 2010). "Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria". Journal of Medicinal Chemistry. 53 (14): 5155–64. doi:10.1021/jm100410f. PMC 6996867. PMID 20568778.
- ^ a b Rottmann, M; McNamara, C; Yeung, BK; Lee, MC; Zou, B; Russell, B; Seitz, P; Plouffe, DM; Dharia, NV; Tan, J; Cohen, SB; Spencer, KR; González-Páez, GE; Lakshminarayana, SB; Goh, A; Suwanarusk, R; Jegla, T; Schmitt, EK; Beck, HP; Brun, R; Nosten, F; Renia, L; Dartois, V; Keller, TH; Fidock, DA; Winzeler, EA; Diagana, TT (3 September 2010). "Spiroindolones, a potent compound class for the treatment of malaria". Science. 329 (5996): 1175–80. Bibcode:2010Sci...329.1175R. doi:10.1126/science.1193225. PMC 3050001. PMID 20813948.
- ^ McNamara, CW; Lee, MC; Lim, CS; Lim, SH; Roland, J; Simon, O; Yeung, BK; Chatterjee, AK; McCormack, SL; Manary, MJ; Zeeman, AM; Dechering, KJ; Kumar, TS; Henrich, PP; Gagaring, K; Ibanez, M; Kato, N; Kuhen, KL; Fischli, C; Nagle, A; Rottmann, M; Plouffe, DM; Bursulaya, B; Meister, S; Rameh, L; Trappe, J; Haasen, D; Timmerman, M; Sauerwein, RW; Suwanarusk, R; Russell, B; Renia, L; Nosten, F; Tully, DC; Kocken, CH; Glynne, RJ; Bodenreider, C; Fidock, DA; Diagana, TT; Winzeler, EA (12 December 2013). "Targeting Plasmodium PI(4)K to eliminate malaria". Nature. 504 (7479): 248–253. Bibcode:2013Natur.504..248M. doi:10.1038/nature12782. PMC 3940870. PMID 24284631.
- ^ Fikes, Bradley (2017-02-18). "Gates Foundation boosts UCSD-led malaria research". San Diego Union Times. Retrieved October 26, 2018.
- ^ Ellison Foundation. "Awards in Malaria". Ellison Foundation. Archived from the original on 10 May 2019. Retrieved 10 May 2019.
- ^ "Keck Foundation Announces 2004 Young Scholars in Medical Research". Philanthropy News Digest (PND). 17 September 2004. Archived from the original on 4 December 2020. Retrieved 4 December 2020.
- ^ Howard T. Ricketts: https://htrl-sites.uchicago.edu/page/about
- ^ "ASTMH - Bailey K. Ashford Medal". www.astmh.org. Archived from the original on 24 October 2020. Retrieved 4 December 2020.
- ^ [s.n.] (March 2, 2016). 78 Fellows Elected to the American Academy of Microbiology Archived 2016-09-11 at the Wayback Machine. Washington, D.C.: American Society of Microbiology. Accessed October 2018.
- ^ Medicines for Malaria Venture: https://www.mmv.org/research-development/project-year-award/mmv-project-year-award-2016
- ^ Alice and C. C. Wang Award: http://www.asbmb.org/awards/wang/
- ^ William Trager Award: http://www.astmh.org/subgroups/acmcip#trager
- ^ Reaching the Last Mile: https://www.reachingthelastmile.com/
- ^ National Academy of Medicine Elects 100 New Members: https://nam.edu/national-academy-of-medicine-elects-100-new-members-2021/
External links
[edit]- Elizabeth A. Winzeler publications indexed by Google Scholar