\documentclass[12pt,border=1pt,crop,multi=false,tikz,class=scrartcl]{standalone} \usepackage[T1]{fontenc} \usepackage[utf8]{inputenc} \usepackage{chemfig,chemmacros} \usepackage{lmodern} \usetikzlibrary{decorations.pathmorphing}  \chemsetup[chemformula]{font-shape=sf,format=\sffamily} \renewcommand*{\familydefault}{\sfdefault} \renewcommand*\printatom[1]{\ensuremath{\mathsf{#1}}} \setatomsep{2em} \setdoublesep{.6ex} \setarrowdefault{,1,semithick} \setbondstyle{thick} %\setarrowlabelsep{1em}  \makeatletter \begin{document} \definesubmol\nobond{-[,0.25,,,draw=none]}  %\schemedebug{true} \schemestart[-90] \subscheme{     \chemfig{R-[:30]@{aa}(=[::60]O)-[::-60]H}     \arrow{->[\chemfig{@{bb}\chemabove{O}{\scriptstyle\ominus}H}]}     \chemfig{R-[:30](-[2]O|\mch)(-[:-80,.9]O@{cc}H)-[:-10]H}     \arrow{->[\chemfig{@{dd}\chemabove{O}{\scriptstyle\ominus}H}]}     \chemfig{R-[:30](-[2]O|\mch)(-[:-80,.9]O|\mch)-[:-10]H}     \chemmove[-stealth, shorten >=2pt, shorten <=1pt]{     	\draw (bb) .. controls +(north west:1mm) and +(north:8mm) .. ($(bb)!.4!(aa)$) .. controls +(south:13mm) and +(south:8mm) .. (aa) ;         \draw (dd) .. controls +(north west:3mm) and +(north:8mm) .. ($(dd)!.45!(cc)$) .. controls +(south:5mm) and +(east:5mm) .. (cc) ;     } } \arrow{0}[,0.2] \subscheme[][west]{ 	\chemfig{R-[:30](-[@{bb}2]O|@{aa}\mch)(-[:-80,.9]OH)-[@{cc}:-10]H}     \arrow{0}[,0]\+\arrow{0}[,0]     \chemfig{R-[:30]@{dd}(=[::60]O)-[::-60]H}     \arrow     \chemfig{R-[:30](=[::60]O)-[::-60]O@{ee}H}     \arrow{0}[,0]\+\arrow{0}[,0]     \chemfig{R-[:30](-[2,,,2]@{ff}\mch O)(-[:-80,.9]H)-[:-10]H}     \arrow     \chemfig{R-[:30](=[::60]O)-[::-60]O\mch}     \arrow{0}[,0]\+\arrow{0}[,0]     \chemfig{R-[:30](-[2]OH)(-[:-80,.9]H)-[:-10]H}     \chemmove[-stealth, shorten >=2pt, shorten <=1pt]{     	\draw (aa) .. controls +(east:5mm) and +(east:5mm) .. (bb);         \draw (cc) .. controls +(north east:8mm) and +(north west:5mm) .. (dd);         \draw (ff) .. controls +(north west:1mm) and +(north:10mm) .. (ee);     } } \arrow{0}[,0.2] \subscheme[][west]{ 	\chemfig{R-[:30](-[@{bb}2]O|@{aa}\mch)(-[:-80,.9]O\mch)-[@{cc}:-10]H}     \arrow{0}[,0]\+\arrow{0}[,0]     \chemfig{R-[:30]@{dd}(=[::60]O)-[::-60]H}     \arrow     \chemfig{R-[:30](=[::60]O)-[::-60]O\mch}     \arrow{0}[,0]\+\arrow{0}[,0]     \chemfig{R-[:30](-[2,,,2]@{ff}\mch O)(-[:-80,.9]H)-[:-10]H}     \arrow{->[\ch{H2O}][(solvent)]}     \chemfig{R-[:30](=[::60]O)-[::-60]O\mch}     \arrow{0}[,0]\+\arrow{0}[,0]     \chemfig{R-[:30](-[2]OH)(-[:-80,.9]H)-[:-10]H}     \chemmove[-stealth, shorten >=2pt, shorten <=1pt]{     	\draw (aa) .. controls +(east:5mm) and +(east:5mm) .. (bb);         \draw (cc) .. controls +(north east:8mm) and +(north west:5mm) .. (dd);      } } \schemestop \end{document}