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Summary
[edit]| Description | http://www.biomedcentral.com/1471-2105/8/365 Design of a computational gene. A) Most eukaryotic genes are organized as alternating sequences of coding (exons) and non-coding (introns) segments. Conserved regions in the introns, e.g., pyrimidine rich region (poly(Y)), 5'-splice junction (AG/GTGAG), AG dinucleotide at the 3'-splice junction, and branch point sequence (CTCAT) guarantee proper splicing. These conserved regions are maintained in the structural moiety of the computational gene. B) Schematic representation of self-assembled (functional) gene encoding a diagnostic rule for 2 mutations (n=2). The initial state comprises promoter, first exon, and 5'-splicing site, the transition rules are placed in the intron region, and the final state includes branch site, poly(Y)-region, 3'-splice site, and second exon. C) Finite state automaton implementing a diagnostic rule for n mutations. |
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| Source | Martinez-Perez, I.M., Zhang, G., Ignatova, Z., Zimmermann, K.-H.: Computational genes: a tool for the molecular diagnosis and therapy of aberrant mutational phenotype. BMC Bioinformatics 2007, 8:365. |
| Date | 28 September 2007 |
| Author | Martinez-Perez et al. |
| Permission (Reusing this file) | GFDL
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[edit] | Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. |
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| current | 19:15, 25 January 2008 | | 842 × 595 (50 KB) | Biomol (talk | contribs) | {{Information |Description= Design of a computational gene. A) Most eukaryotic genes are organized as alternating sequences of coding (exons) and non-coding (introns) segments. Conserved regions in the introns, e.g., pyrimidine rich region (poly(Y)), 5'- |
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