English: Synthesis of guanfacine from 2,6-dichlorophenylacetic acid methyl ester and guanidine as described in United States Patent 3,632,645 Substituted phenylacetyl derivatives of guanidine o-alkylisoureas s-alkylisothioureas and p-nitrobenzylisothiourea, John Bernard Bream, Redbourn, Herts, and Claude W. Picard
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