Protein-coding gene in humans
GOPC Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DC2 , 2LOB , 4E34 , 4E35 , 4JOE , 4JOF , 4JOG , 4JOH , 4JOJ , 4JOK , 4JOP , 4JOR , 4K6Y , 4K72 , 4K75 , 4K76 , 4K78 , 4NMO , 4NMP , 4NMQ , 4NMR , 4NMS , 4NMT , 4NMV , 4Q6H , 4Q6S
Identifiers Aliases GOPC External IDs OMIM : 606845 ; MGI : 2149946 ; HomoloGene : 10695 ; GeneCards : GOPC ; OMA :GOPC - orthologs RNA expression patternBgee Human Mouse (ortholog)Top expressed in tibia pancreatic epithelial cell parietal pleura visceral pleura secondary oocyte germinal epithelium middle temporal gyrus skin of arm tendon of biceps brachii Achilles tendon
Top expressed in trigeminal ganglion medullary collecting duct dorsomedial hypothalamic nucleus piriform cortex lumbar spinal ganglion dentate gyrus of hippocampal formation granule cell ascending aorta epithelium of lens right kidney atrioventricular valve
More reference expression data
BioGPS
Wikidata
Golgi-associated PDZ and coiled-coil motif-containing protein is a protein that in humans is encoded by the GOPC gene .[ 5] [ 6] [ 7]
PIST is a PDZ domain-containing Golgi protein. PDZ domains contain approximately 90 amino acids and bind the extreme C terminus of proteins in a sequence-specific manner.[supplied by OMIM][ 7]
GOPC has been shown to interact with GRID2 ,[ 8] BECN1 ,[ 8] RHOQ ,[ 5] ACCN3 ,[ 9] Cystic fibrosis transmembrane conductance regulator [ 10] [ 11] CSPG5 .[ 12]
^ a b c GRCh38: Ensembl release 89: ENSG00000047932 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019861 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Neudauer CL, Joberty G, Macara IG (Feb 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem Biophys Res Commun . 280 (2): 541–7. doi :10.1006/bbrc.2000.4160 . PMID 11162552 . ^ Yao R, Maeda T, Takada S, Noda T (Aug 2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled". Biochem Biophys Res Commun . 286 (4): 771–8. doi :10.1006/bbrc.2001.5430 . PMID 11520064 . ^ a b "Entrez Gene: GOPC golgi associated PDZ and coiled-coil motif containing" .^ a b Yue, Zhenyu; Horton Antony; Bravin Monica; DeJager Philip L; Selimi Fekrije; Heintz Nathaniel (Aug 2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice" . Neuron . 35 (5). United States: 921–33. doi :10.1016/S0896-6273(02)00861-9 ISSN 0896-6273 . PMID 12372286 . S2CID 10534933 . ^ Hruska-Hageman, Alesia M; Benson Christopher J; Leonard A Soren; Price Margaret P; Welsh Michael J (Nov 2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current" . J. Biol. Chem . 279 (45). United States: 46962–8. doi :10.1074/jbc.M405874200 ISSN 0021-9258 . PMID 15317815 . ^ Cheng, Jie; Moyer Bryan D; Milewski Michal; Loffing Johannes; Ikeda Masahiro; Mickle John E; Cutting Garry R; Li Min; Stanton Bruce A; Guggino William B (Feb 2002). "A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression" . J. Biol. Chem . 277 (5). United States: 3520–9. doi :10.1074/jbc.M110177200 ISSN 0021-9258 . PMID 11707463 . ^ Gentzsch, Martina; Cui Liying; Mengos April; Chang Xiu-Bao; Chen Jey-Hsin; Riordan John R (Feb 2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins" . J. Biol. Chem . 278 (8). United States: 6440–9. doi :10.1074/jbc.M211050200 ISSN 0021-9258 . PMID 12471024 . ^ Hassel, Burkhard; Schreff Matthias; Stube Eva-Maria; Blaich Uta; Schumacher Stefan (Oct 2003). "CALEB/NGC interacts with the Golgi-associated protein PIST" . J. Biol. Chem . 278 (41). United States: 40136–43. doi :10.1074/jbc.M305577200 ISSN 0021-9258 . PMID 12885772 . Loo MA, Jensen TJ, Cui L, et al. (1999). "Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome" . EMBO J . 17 (23): 6879–87. doi :10.1093/emboj/17.23.6879 . PMC 1171036 PMID 9843494 . Charest A, Lane K, McMahon K, Housman DE (2001). "Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6" . J. Biol. Chem . 276 (31): 29456–65. doi :10.1074/jbc.M104137200 PMID 11384996 . Cheng J, Moyer BD, Milewski M, et al. (2002). "A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression" . J. Biol. Chem . 277 (5): 3520–9. doi :10.1074/jbc.M110177200 PMID 11707463 . Yao R, Ito C, Natsume Y, et al. (2002). "Lack of acrosome formation in mice lacking a Golgi protein, GOPC" . Proc. Natl. Acad. Sci. U.S.A . 99 (17): 11211–6. Bibcode :2002PNAS...9911211Y . doi :10.1073/pnas.162027899 PMC 123235 PMID 12149515 . Yue Z, Horton A, Bravin M, et al. (2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice" . Neuron . 35 (5): 921–33. doi :10.1016/S0896-6273(02)00861-9 PMID 12372286 . S2CID 10534933 . Gentzsch M, Cui L, Mengos A, et al. (2003). "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins" . J. Biol. Chem . 278 (8): 6440–9. doi :10.1074/jbc.M211050200 PMID 12471024 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Charest A, Kheifets V, Park J, et al. (2003). "Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma" . Proc. Natl. Acad. Sci. U.S.A . 100 (3): 916–21. Bibcode :2003PNAS..100..916C . doi :10.1073/pnas.242741799 PMC 298701 PMID 12538861 . Charest A, Lane K, McMahon K, et al. (2003). "Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)". Genes Chromosomes Cancer . 37 (1): 58–71. doi :10.1002/gcc.10207 . PMID 12661006 . S2CID 39776967 . Hassel B, Schreff M, Stube EM, et al. (2003). "CALEB/NGC interacts with the Golgi-associated protein PIST" . J. Biol. Chem . 278 (41): 40136–43. doi :10.1074/jbc.M305577200 PMID 12885772 . Cheng J, Wang H, Guggino WB (2004). "Modulation of mature cystic fibrosis transmembrane regulator protein by the PDZ domain protein CAL" . J. Biol. Chem . 279 (3): 1892–8. doi :10.1074/jbc.M308640200 PMID 14570915 . Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805–11. Bibcode :2003Natur.425..805M . doi :10.1038/nature02055 PMID 14574404 . Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem . 76 (10): 2763–72. doi :10.1021/ac035352d . PMID 15144186 . Hruska-Hageman AM, Benson CJ, Leonard AS, et al. (2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current" . J. Biol. Chem . 279 (45): 46962–8. doi :10.1074/jbc.M405874200 PMID 15317815 . He J, Bellini M, Xu J, et al. (2005). "Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression" . J. Biol. Chem . 279 (48): 50190–6. doi :10.1074/jbc.M404876200 PMID 15358775 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Cheng J, Wang H, Guggino WB (2005). "Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10" . J. Biol. Chem . 280 (5): 3731–9. doi :10.1074/jbc.M410026200 PMID 15546864 . Hicks SW, Machamer CE (2005). "Isoform-specific interaction of golgin-160 with the Golgi-associated protein PIST" . J. Biol. Chem . 280 (32): 28944–51. doi :10.1074/jbc.M504937200 PMID 15951434 .
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