Glutamate rich 5

ERICH5
Identifiers
Aliases	ERICH5, C8orf47, glutamate rich 5
External IDs	MGI: 2447772; HomoloGene: 52129; GeneCards: ERICH5; OMA:ERICH5 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.2 Start 98,064,522 bp[1] End 98,093,610 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 B3.1 Start 34,453,451 bp[2] End 34,474,038 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva bronchial epithelial cell islet of Langerhans mucosa of paranasal sinus body of pancreas olfactory zone of nasal mucosa right uterine tube gallbladder testicle oocyte Top expressed in zygote primary oocyte secondary oocyte lens neural layer of retina stomach embryo dentate gyrus of hippocampal formation granule cell duodenum morula More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 203111 239368 Ensembl ENSG00000177459 ENSMUSG00000044726 UniProt Q6P6B1 Q8K0S2 RefSeq (mRNA) NM_173549 NM_001170806 NM_173421 RefSeq (protein) NP_001164277 NP_775820 NP_775597 Location (UCSC) Chr 8: 98.06 – 98.09 Mb Chr 15: 34.45 – 34.47 Mb PubMed search [3] [4]
Wikidata
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Glutamate rich protein 5 is a protein in humans encoded by the ERICH5 gene, also known as chromosome 8 open reading frame 47 (C8orf47).

The ERICH5 gene is located on human chromosome 8 at 8q22.2 and spans 29 kb on the plus strand of the DNA.^[5] ERICH5 contains three exons and two introns.^[6] ERICH5 is also known as C8orf47 and glutamate rich 5.^[5]

The ERICH5 protein has two isofroms. The longest isofrom, isofrom 1, spans 1,550 base pairs and is composed of 374 amino acids. The second isoform lacks the third and final exon and is 596 base pairs long.^[6]

ERICH5 contains one conserved domain, a domain of unknown function called DUF4573.^[7] ERICH5 is predicted to contain two highly conserved motifs, an APC/C binding motif and the LIG_FHA_2 motif.^[8] The APC/C motif spans amino acid 222-226 and serves as a binding site for the anaphase-promoting complex.^[9] The LIG_FHA_2 motif is involved in the cell checkpoint pathway and is found in many proteins localized in the nucleus that regulate cell cycle.^[10]

ERICH5 is predicted to undergo several post-translational modifications including phosphorylation, O-glycosylation, and sumoylation.^[11][12][13] Many of the phosphorylation sites and O-glycosylation sites were predicted at the same amino acid. The post translational modifications shown are those conserved among ERICH5 orthologs. Several kinases were predicted to phosphorylate ERICH5 including PKC, cdc2, CKI, PKA, DNAPK, ATM, EGFR, and CKII.^[11]

ERICH5 was predicted to contain three alpha helices and two beta sheets as well as regions of random coils.^[14]

ERICH5 was predicted to be localized in the nucleus.^[16]

ERICH5 was predicted to interact with several proteins through yeast two-hybrid screening and affinity chromatography.^[15] Several of the proteins ERICH5 was predicted to interact with were also localized in the nucleus.^[15]

ERICH5 shows elevated levels of expression in the fetal liver, liver, pancreas, and retina compared to other tissues.

ERICH5 shows increased expression in Alcoholic Hepatitis.

There are no known paralogs of ERICH5.^[19]

True orthologs of ERICH5 have only been identified among mammalian species. The most distantly related mammalian ortholog is in Monodelphis domestica, or the gray short-tailed opossum.^[20]

ERICH5 has distant orthologs among birds and reptiles. These distant orthologs contain only the third exon of ERICH5.^[20]