HARS2

HARS2
Identifiers
AliasesHARS2, HARSL, HARSR, HO3, PRLTS2, histidyl-tRNA synthetase 2, mitochondrial, HisRS
External IDsOMIM: 600783; MGI: 1918041; HomoloGene: 40819; GeneCards: HARS2; OMA:HARS2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278731
NM_001278732
NM_012208
NM_001363535
NM_001363536

NM_080636
NM_001305627
NM_001360921

RefSeq (protein)

NP_001265660
NP_001265661
NP_036340
NP_001350464
NP_001350465

NP_001292556
NP_542367
NP_001347850

Location (UCSC)Chr 5: 140.69 – 140.7 MbChr 18: 36.92 – 36.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable histidyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the HARS2 gene.[5][6]

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes share a bidirectional promoter.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112855Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019143Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ O'Hanlon TP, Raben N, Miller FW (Jun 1995). "A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS". Biochem Biophys Res Commun. 210 (2): 556–66. doi:10.1006/bbrc.1995.1696. PMID 7755634.
  6. ^ a b "Entrez Gene: HARS2 histidyl-tRNA synthetase 2, mitochondrial (putative)".

Further reading

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