Haplogroup R-Z18

R-Z18 is a subclade of the R-U106 branch of Haplogroup R1b. It includes all men who have the single nucleotide polymorphism (SNP) designated Z18 in their Y chromosome.

Description

R-Z18, also called R-Z19, is defined to be mutation in which the nucleotide at position 14,991,735^[1] along the Y chromosome that has mutated from guanine (G) to adenine (A). R-U106 is one of the major sub groups of R1b in Europe, but Z18 only makes up about 5-10% of R-U106.

Discovery

Z18 was discovered during Phase 3 of the 1000 Genomes Project^[2] and entered on 16 August 2014 into the SNP database dbSNP at the National Center for Biotechnology Information as reference SNP cluster report rs767290651.^[3]

History and distribution

The R-Z18 subclade was formed around approximately 2850 BCE.^[1] It is a subclade of haplogroup R-U106, one of the principal R1b lineages in Europe. The earliest R-U106 sample was found in what is now Bohemia, among the early Corded Ware Culture.^[3] R-Z18 most likely formed somewhere in Northern Germany or Southern Scandinavia. The earliest R-Z18 sample identified is from late Neolithic Zealand, Denmark.

R-Z18 samples dating to the Late Neolithic and Nordic Bronze Age have been found in Denmark and southern Sweden.^[4] Samples from the Iron Age, in addition to Denmark and southern Sweden, have also been found in northern Norway, northeastern Germany, and in the Wielbark Culture of northern Poland.^[5] By the Migration Period and Viking Age samples are found in northwestern Germany, Bavaria, Hungary, Flanders, Anglo-Saxon England, Scandinavia, Iceland, and parts of the British Isles influenced by Scandinavians. Samples from the later Middle Ages and Early Modern Period have been found in Jutland, Cambridgeshire, and in the wreck of the Kronan.^[6]^[7]^[8]

R-Z18 has its highest concentrations in Norway and Sweden, but is also found throughout areas of Germanic migration, including the Low Countries, British Isles, and Central Europe. It is also present at lower frequencies across Europe, as well as in areas of the world settled by Europeans.^[9]^[10] R-Z18's early presence in Scandinavia indicate a likely origin in the region, with subsequent migrations of Germanic peoples during the Migration Era and Viking Age spreading the haplogroup around Europe.

Subclades

Major known subclades of R-Z18 include R-ZP156, R-S11601, R-DF95, R-FGC7637, R-Z2396, R-S6119 and R-Z17.^[11] Although they continue to increase as more are found.

References

^ ^a ^b This position is with respect to human reference genome assembly GRCh37/hg19 released on March 7, 2009 by the Genome Reference Consortium. https://www.ncbi.nlm.nih.gov/projects/genome/assembly/grc/human/
^ 1000 Genomes Project, http://www.1000genomes.org/
^ ^a ^b National Center for Biotechnology Information, dbSNP Short Genetic Variations, https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=767290651
^ "Steppe Ancestry in western Eurasia and the spread of the Germanic Languages".
^ "Welcome to FamilyTreeDNA Discover". FamilyTreeDNA Discover. Retrieved 2024-09-18.
^ Barrie, William; Yang, Yaoling; Irving-Pease, Evan K.; Attfield, Kathrine E.; Scorrano, Gabriele; Jensen, Lise Torp; Armen, Angelos P.; Dimopoulos, Evangelos Antonios; Stern, Aaron; Refoyo-Martinez, Alba; Pearson, Alice; Ramsøe, Abigail; Gaunitz, Charleen; Demeter, Fabrice; Jørkov, Marie Louise S. (January 2024). "Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations". Nature. 625 (7994): 321–328. doi:10.1038/s41586-023-06618-z. ISSN 1476-4687. PMC 10781639.
^ Hui, Ruoyun; Scheib, Christiana L.; D’Atanasio, Eugenia; Inskip, Sarah A.; Cessford, Craig; Biagini, Simone A.; Wohns, Anthony W.; Ali, Muhammad Q. A.; Griffith, Samuel J. (2023-03-06), Medieval social landscape through the genetic history of Cambridgeshire before and after the Black Death, doi:10.1101/2023.03.03.531048, retrieved 2024-10-04
^ R, Rodríguez-Varela; Khs, Moore; Ss, Ebenesersdóttir; Gm, Kilinc; A, Kjellström; L, Papmehl-Dufay; C, Alfsdotter; B, Berglund; L, Alrawi; N, Kashuba; V, Sobrado; Vk, Lagerholm; E, Gilbert; Gl, Cavalleri; E, Hovig (2023-01-05). "The genetic history of Scandinavia from the Roman Iron Age to the present". Cell. 186 (1). doi:10.1016/j.cell.2022.11.024. hdl:10810/60423. ISSN 1097-4172. PMID 36608656.
^ McDonald, Iain. "U106 explored: its relationships, geography, and history" (PDF).
^ "Welcome to FamilyTreeDNA Discover". FamilyTreeDNA Discover. Retrieved 2024-10-05.
^ Peter Op den Velde Boots, R-Z18 A North Sea Tribe, http://l257.groenebeverbv.nl/ Archived 2011-08-03 at the Wayback Machine

External links

L257 A North Sea Tribe Archived 2011-08-03 at the Wayback Machine

[vanOven2014-12] Van Oven M, Van Geystelen A, Kayser M, Decorte R, Larmuseau HD (2014). "Seeing the wood for the trees: a minimal reference phylogeny for the human Y chromosome". Human Mutation. 35 (2): 187–91. doi:10.1002/humu.22468. PMID 24166809. S2CID 23291764.

[ISOGG2015-13] International Society of Genetic Genealogy (ISOGG; 2015), Y-DNA Haplogroup Tree 2015. (Access date: 1 February 2015.)

[A0-T-14] Haplogroup A0-T is also known as A-L1085 (and previously as A0'1'2'3'4).

[A1-15] Haplogroup A1 is also known as A1'2'3'4.

[F-Y27277-16] F-Y27277, sometimes known as F2'4, is both the parent clade of F2 and F4 and a child of F-M89.

[LT-17] Haplogroup LT (L298/P326) is also known as Haplogroup K1.

[K2-18] Between 2002 and 2008, Haplogroup T-M184 was known as "Haplogroup K2". That name has since been re-assigned to K-M526, the sibling of Haplogroup LT.

[K2b-19] Haplogroup K2b (M1221/P331/PF5911) is also known as Haplogroup MPS.

[K2b1-20] Haplogroup K2b1 (P397/P399) is also known as Haplogroup MS, but has a broader and more complex internal structure.

[P-21] Haplogroup P (P295) is also klnown as K2b2.

[K-M2313-22] K-M2313*, which as yet has no phylogenetic name, has been documented in two living individuals, who have ethnic ties to India and South East Asia. In addition, K-Y28299, which appears to be a primary branch of K-M2313, has been found in three living individuals from India. See: Poznik op. cit.; YFull YTree v5.08, 2017, "K-M2335", and; PhyloTree, 2017, "Details of the Y-SNP markers included in the minimal Y tree" (Access date of these pages: 9 December 2017)

[S-23] Haplogroup S, as of 2017, is also known as K2b1a. (Previously the name Haplogroup S was assigned to K2b1a4.)

[M-24] Haplogroup M, as of 2017, is also known as K2b1b. (Previously the name Haplogroup M was assigned to K2b1d.)

[:0-1] This position is with respect to human reference genome assembly GRCh37/hg19 released on March 7, 2009 by the Genome Reference Consortium. https://www.ncbi.nlm.nih.gov/projects/genome/assembly/grc/human/

[2] 1000 Genomes Project, http://www.1000genomes.org/

[:1-3] National Center for Biotechnology Information, dbSNP Short Genetic Variations, https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?rs=767290651

[:2-4] "Steppe Ancestry in western Eurasia and the spread of the Germanic Languages".

[:3-5] "Welcome to FamilyTreeDNA Discover". FamilyTreeDNA Discover. Retrieved 2024-09-18.

[6] Barrie, William; Yang, Yaoling; Irving-Pease, Evan K.; Attfield, Kathrine E.; Scorrano, Gabriele; Jensen, Lise Torp; Armen, Angelos P.; Dimopoulos, Evangelos Antonios; Stern, Aaron; Refoyo-Martinez, Alba; Pearson, Alice; Ramsøe, Abigail; Gaunitz, Charleen; Demeter, Fabrice; Jørkov, Marie Louise S. (January 2024). "Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations". Nature. 625 (7994): 321–328. doi:10.1038/s41586-023-06618-z. ISSN 1476-4687. PMC 10781639.

[7] Hui, Ruoyun; Scheib, Christiana L.; D’Atanasio, Eugenia; Inskip, Sarah A.; Cessford, Craig; Biagini, Simone A.; Wohns, Anthony W.; Ali, Muhammad Q. A.; Griffith, Samuel J. (2023-03-06), Medieval social landscape through the genetic history of Cambridgeshire before and after the Black Death, doi:10.1101/2023.03.03.531048, retrieved 2024-10-04

[8] R, Rodríguez-Varela; Khs, Moore; Ss, Ebenesersdóttir; Gm, Kilinc; A, Kjellström; L, Papmehl-Dufay; C, Alfsdotter; B, Berglund; L, Alrawi; N, Kashuba; V, Sobrado; Vk, Lagerholm; E, Gilbert; Gl, Cavalleri; E, Hovig (2023-01-05). "The genetic history of Scandinavia from the Roman Iron Age to the present". Cell. 186 (1). doi:10.1016/j.cell.2022.11.024. hdl:10810/60423. ISSN 1097-4172. PMID 36608656.

[:4-9] McDonald, Iain. "U106 explored: its relationships, geography, and history" (PDF).

[10] "Welcome to FamilyTreeDNA Discover". FamilyTreeDNA Discover. Retrieved 2024-10-05.

[11] Peter Op den Velde Boots, R-Z18 A North Sea Tribe, http://l257.groenebeverbv.nl/ Archived 2011-08-03 at the Wayback Machine

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