Homoaconitate hydratase
homoaconitate hydratase | |||||||||
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![]() Homoaconitate hydratase homodimer, Methanocaldococcus jannaschii | |||||||||
Identifiers | |||||||||
EC no. | 4.2.1.36 | ||||||||
CAS no. | 9030-68-6 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme homoaconitate hydratase (EC 4.2.1.36) catalyzes the chemical reaction
- (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]. Other names in common use include homoaconitase, cis-homoaconitase, HACN, Lys4, LysF, and 2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase (incorrect). This enzyme participates in lysine biosynthesis.
References
[edit]- Strassman M, Ceci LN (1966). "Enzymatic formation of cis-homoaconitic acid, an intermediate in lysine biosynthesis in yeast". J. Biol. Chem. 241 (22): 5401–7. PMID 5954805.
- Jia Y, Tomita T, Yamauchi K, Nishiyama M, Palmer DR (2006). "Kinetics and product analysis of the reaction catalysed by recombinant homoaconitase from Thermus thermophilus". Biochem. J. 396 (3): 479–85. doi:10.1042/BJ20051711. PMC 1482822. PMID 16524361.
- Zabriskie TM, Jackson MD (2000). "Lysine biosynthesis and metabolism in fungi". Nat. Prod. Rep. 17 (1): 85–97. doi:10.1039/a801345d. PMID 10714900.