| Name | Location | Type | Date | Notes/References |
| Estádio Nacional 12 de Julho | 0°20′06″N 6°44′15″E / 0.335083°N 6.7375°E / 0.335083; 6.7375 | Stadium | 20th century | Remodeled in 2002, expanded in 2003, operated by Federação Santomense de Futebol. |
| International Bank of São Tomé and Príncipe | 0°20′23″N 6°43′45″E / 0.3397669°N 6.7291153°E / 0.3397669; 6.7291153 | Bank | 20th century | Portuguese: Banco Internacional de Sao Tome e Principe |
| Lagoa Azul Lighthouse | 0°23′59″N 6°36′17″E / 0.3997425°N 6.6047207°E / 0.3997425; 6.6047207 | Lighthouse | 1997 | Built as part of a project by the Portuguese Navy and powered by solar energy. |
| National Assembly | 0°19′53″N 6°44′26″E / 0.331389°N 6.740556°E / 0.331389; 6.740556 | Government building | | Portuguese: Assembleia Nacional de São Tomé e Príncipe. |
| National Library of São Tomé e Príncipe | 0°20′21″N 6°44′00″E / 0.339062°N 6.733215°E / 0.339062; 6.733215 | Library | 2002 | Portuguese: Biblioteca Nacional de São Tomé e Príncipe. |
| National Lyceum | 0°20′19″N 6°44′26″E / 0.338611°N 6.740556°E / 0.338611; 6.740556 | School | 20th century | |
| Our Lady of Grace Cathedral, São Tomé | 0°20′18″N 6°43′57″E / 0.338333°N 6.7325°E / 0.338333; 6.7325 | Church | 1814 | Portuguese: Sé Catedral de Nossa Senhora da Graça de São Tomé. |
| Presidential Palace of São Tomé e Príncipe | 0°20′21″N 6°44′00″E / 0.339062°N 6.733215°E / 0.339062; 6.733215 | Government building | Mid-19th century | Architect unknown, renovated in 1954.[1] |
| Príncipe Airport | 1°39′46″N 7°24′42″E / 1.662778°N 7.411667°E / 1.662778; 7.411667 | Airport | 1968 | Renovation completed in 2015. |
| University of São Tomé and Príncipe | 0°19′34″N 6°43′42″E / 0.3261039°N 6.7283052°E / 0.3261039; 6.7283052 | School | 1996 | Formerly named Instituto Superior Politécnico. |
| São Sebastião Lighthouse | 0°20′00″N 6°44′00″E / 0.333333°N 6.733333°E / 0.333333; 6.733333 | Lighthouse | 1928 | Located adjacent to the National Museum of History and Art. |
| São Sebastião Museum | 0°20′45″N 6°44′22″E / 0.345833°N 6.739444°E / 0.345833; 6.739444 | Museum | 1976 | Located on the site of the first fort in the island of São Tomé. |
| São Tomé International Airport | 0°22′41″N 6°42′44″E / 0.378056°N 6.712222°E / 0.378056; 6.712222 | Airport | 20th century | Administered by Empresa Nacional de Aeroportos e Segurança Área. |
| Supreme Court of São Tomé and Príncipe | 0°20′23″N 6°44′00″E / 0.339744°N 6.733433°E / 0.339744; 6.733433 | Government building | 1976 | Portuguese: Supremo Tribunal de Justiça. |