MOCS3

MOCS3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMOCS3, UBA4, molybdenum cofactor synthesis 3
External IDsOMIM: 609277; MGI: 1916622; HomoloGene: 6108; GeneCards: MOCS3; OMA:MOCS3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014484

NM_001160330

RefSeq (protein)

NP_055299

NP_001153802

Location (UCSC)Chr 20: 50.96 – 50.96 MbChr 2: 168.07 – 168.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Adenylyltransferase and sulfurtransferase MOCS3 is an enzyme that in humans is encoded by the MOCS3 gene.[5][6]

Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. One of the enzymes required for the biosynthesis of MoCo is molybdopterin synthase (MPT synthase, encoded by MOCS2/Mocs2 in mammals). The protein encoded by this gene adenylates and activates MPT synthase. This gene contains no introns. A pseudogene of this gene is present on chromosome 14.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124217Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074576Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Matthies A, Nimtz M, Leimkuhler S (May 2005). "Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry". Biochemistry. 44 (21): 7912–20. doi:10.1021/bi0503448. PMID 15910006.
  6. ^ a b "Entrez Gene: MOCS3 molybdenum cofactor synthesis 3".

Further reading

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