MRPS11

MRPS11
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPS11, HCC-2, MRP-S11, S11mt, mitochondrial ribosomal protein S11
External IDsOMIM: 611977; MGI: 1915244; HomoloGene: 32554; GeneCards: MRPS11; OMA:MRPS11 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_026498
NM_001360702

RefSeq (protein)

n/a

Location (UCSC)Chr 15: 88.47 – 88.48 MbChr 7: 78.43 – 78.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

28S ribosomal protein S11, mitochondrial is a protein that in humans is encoded by the MRPS11 gene.[5][6]

Function

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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181991Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030611Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Suzuki T, Terasaki M, Takemoto-Hori C, Hanada T, Ueda T, Wada A, Watanabe K (Aug 2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit". J Biol Chem. 276 (35): 33181–95. doi:10.1074/jbc.M103236200. PMID 11402041.
  6. ^ a b "Entrez Gene: MRPS11 mitochondrial ribosomal protein S11".

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: P82912 (28S ribosomal protein S11, mitochondrial) at the PDBe-KB.