Mycothiol synthase

Mycothiol synthase
Identifiers
EC no.2.3.1.189
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

Mycothiol synthase (EC 2.3.1.189, MshD) is an enzyme with systematic name acetyl-CoA:desacetylmycothiol O-acetyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

desacetylmycothiol + acetyl-CoA CoA + mycothiol

This enzyme catalyses the last step in the biosynthesis of mycothiol

References

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  1. ^ Spies HS, Steenkamp DJ (August 1994). "Thiols of intracellular pathogens. Identification of ovothiol A in Leishmania donovani and structural analysis of a novel thiol from Mycobacterium bovis". European Journal of Biochemistry. 224 (1): 203–13. doi:10.1111/j.1432-1033.1994.tb20013.x. PMID 8076641.
  2. ^ Koledin T, Newton GL, Fahey RC (November 2002). "Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes". Archives of Microbiology. 178 (5): 331–7. doi:10.1007/s00203-002-0462-y. PMID 12375100.
  3. ^ Vetting MW, Roderick SL, Yu M, Blanchard JS (September 2003). "Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases". Protein Science. 12 (9): 1954–9. doi:10.1110/ps.03153703. PMC 2323992. PMID 12930994.
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