Protein-coding gene in the species Homo sapiens
Osteoclast-associated immunoglobulin-like receptor is a protein that in humans is encoded by the OSCAR gene .[ 5] [ 6]
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis . This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses . Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.[ 6]
^ a b c ENSG00000170909, ENSG00000274703, ENSG00000276982, ENSG00000278533, ENSG00000275736, ENSG00000275551, ENSG00000278378, ENSG00000273511, ENSG00000275644 GRCh38: Ensembl release 89: ENSG00000277088, ENSG00000170909, ENSG00000274703, ENSG00000276982, ENSG00000278533, ENSG00000275736, ENSG00000275551, ENSG00000278378, ENSG00000273511, ENSG00000275644 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054594 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Kim N, Takami M, Rho J, Josien R, Choi Y (Jan 2002). "A novel member of the leukocyte receptor complex regulates osteoclast differentiation" . J Exp Med . 195 (2): 201–9. doi :10.1084/jem.20011681 . PMC 2193610 PMID 11805147 . ^ a b "Entrez Gene: OSCAR osteoclast-associated receptor" . Pupello DF, Lipton M, Shumway NE (1976). "An unusual case of a bullet embolus". The Journal of the Florida Medical Association . 62 (11): 51. PMID 1185147 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Merck E, Gaillard C, Gorman DM, et al. (2004). "OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells" . Blood . 104 (5): 1386–95. doi :10.1182/blood-2004-03-0850 PMID 15155468 . Merck E, de Saint-Vis B, Scuiller M, et al. (2005). "Fc receptor gamma-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses" . Blood . 105 (9): 3623–32. doi :10.1182/blood-2004-07-2809 PMID 15650060 . Tenca C, Merlo A, Merck E, et al. (2005). "CD85j (leukocyte Ig-like receptor-1/Ig-like transcript 2) inhibits human osteoclast-associated receptor-mediated activation of human dendritic cells" . J. Immunol . 174 (11): 6757–63. doi :10.4049/jimmunol.174.11.6757 PMID 15905516 . Kim GS, Koh JM, Chang JS, et al. (2005). "Association of the OSCAR promoter polymorphism with BMD in postmenopausal women" . J. Bone Miner. Res . 20 (8): 1342–8. doi :10.1359/JBMR.050320 PMID 16007331 . S2CID 23162197 . Kim K, Kim JH, Lee J, et al. (2005). "Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis" . J. Biol. Chem . 280 (42): 35209–16. doi :10.1074/jbc.M505815200 PMID 16109714 . Merck E, Gaillard C, Scuiller M, et al. (2006). "Ligation of the FcR gamma chain-associated human osteoclast-associated receptor enhances the proinflammatory responses of human monocytes and neutrophils" . J. Immunol . 176 (5): 3149–56. doi :10.4049/jimmunol.176.5.3149 PMID 16493074 .
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