Protein-coding gene in the species Homo sapiens
Paternally-expressed gene 3 protein is a protein that in humans is encoded by the PEG3 gene .[ 5] [ 6] imprinted gene expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction.[ 7] sequence motif AGTnnCnnnTGGCT, which it binds to using multiple Kruppel-like factors . It also regulate the expression of Pgm2l1 through the binding of the motif.[ 8]
PEG3 has been shown to interact with SIAH2 [ 9] SIAH1 .[ 9]
^ a b c GRCh38: Ensembl release 89: ENSG00000198300 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002265 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Kim J, Ashworth L, Branscomb E, Stubbs L (August 1997). "The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4" . Genome Res . 7 (5): 532–40. doi :10.1101/gr.7.5.532 . PMC 310658 PMID 9149948 . ^ "Entrez Gene: PEG3 paternally expressed 3" .^ Michelle M. Thiaville; Jennifer M. Huang; Hana Kim; Muhammad B. Ekram; Arundhati Bakshi; Tae-Young Roh; Joomyeong Kim (December 31, 2013). "Peg3 Mutational Effects on Reproduction and Placenta-Specific Gene Families" . PLOS ONE . 8 (12): e83359. Bibcode :2013PLoSO...883359K . doi :10.1371/journal.pone.0083359 PMC 3877027 PMID 24391757 . ^ Thiaville MM, Huang JM, Kim H, Ekram MB, Roh TY, Kim J (January 2013). "DNA-binding motif and target genes of the imprinted transcription factor PEG3" . Gene . 512 (2): 314–320. doi :10.1016/j.gene.2012.10.005 . PMC 3513644 PMID 23078764 . ^ a b Relaix, F; Wei X j; Li W; Pan J; Lin Y; Bowtell D D; Sassoon D A; Wu X (February 2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis" . Proc. Natl. Acad. Sci. U.S.A. 97 (5). UNITED STATES: 2105–10. Bibcode :2000PNAS...97.2105R . doi :10.1073/pnas.040378897 ISSN 0027-8424 . PMC 15761 PMID 10681424 . Relaix F, Wei XJ, Wu X, Sassoon DA (1998). "Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway". Nat. Genet . 18 (3): 287–91. doi :10.1038/ng0398-287 . PMID 9500555 . S2CID 1235332 . Relaix F, Wei X, Li W, et al. (2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis" . Proc. Natl. Acad. Sci. U.S.A . 97 (5): 2105–10. Bibcode :2000PNAS...97.2105R . doi :10.1073/pnas.040378897 PMC 15761 PMID 10681424 . Kim J, Bergmann A, Stubbs L (2000). "Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3)" . Genomics . 64 (1): 114–8. doi :10.1006/geno.1999.6112 . PMID 10708526 . Kohda T, Asai A, Kuroiwa Y, et al. (2001). "Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line" . Genes Cells . 6 (3): 237–47. doi :10.1046/j.1365-2443.2001.00412.x PMID 11260267 . S2CID 43806250 . Hiby SE, Lough M, Keverne EB, et al. (2001). "Paternal monoallelic expression of PEG3 in the human placenta". Hum. Mol. Genet . 10 (10): 1093–100. doi :10.1093/hmg/10.10.1093 . PMID 11331620 . Yarden RI, Brody LC (2002). "Identification of proteins that interact with BRCA1 by Far-Western library screening" . J. Cell. Biochem . 83 (4): 521–31. doi :10.1002/jcb.1257 . PMID 11746496 . S2CID 29703139 . Johnson MD, Wu X, Aithmitti N, Morrison RS (2002). "Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death" . J. Biol. Chem . 277 (25): 23000–7. doi :10.1074/jbc.M201907200 PMID 11943780 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Mirey G, Chartrain I, Froment C, et al. (2006). "CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis" . Cell Cycle . 4 (6): 806–11. doi :10.4161/cc.4.6.1716 PMID 15908796 . Dowdy SC, Gostout BS, Shridhar V, et al. (2005). "Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines". Gynecol. Oncol . 99 (1): 126–34. doi :10.1016/j.ygyno.2005.05.036 . PMID 16023706 . Chartrain I, Couturier A, Tassan JP (2006). "Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells" . Biol. Cell . 98 (4): 253–63. doi :10.1042/BC20050041 PMID 16159311 . S2CID 45211094 . Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14. doi :10.1016/j.cell.2006.03.032 PMID 16713569 . S2CID 13709685 .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
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