PIR (gene)

PIR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ERO, 4EWD, 4GUL, 1J1L, 4EWA, 4HLT, 3ACL, 4EWE
Identifiers
Aliases	PIR, pirin
External IDs	OMIM: 300931; MGI: 1916906; HomoloGene: 2717; GeneCards: PIR; OMA:PIR - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	15,493,564 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	163,156,007 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; gonad; ; right lung; ; right adrenal gland; ; right adrenal cortex; ; urinary bladder; ; olfactory zone of nasal mucosa; ; left adrenal gland; ; left adrenal cortex; ; islet of Langerhans;
	Top expressed in
	esophagus; ; lumbar spinal ganglion; ; olfactory epithelium; ; embryo; ; left lobe of liver; ; lip; ; right lung; ; conjunctival fornix; ; transitional epithelium of urinary bladder; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; protein binding; transcription coregulator activity; dioxygenase activity; metal ion binding; quercetin 2,3-dioxygenase activity;
Cellular component	cytoplasm; nucleus; cytosol; nucleoplasm;
Biological process	myeloid cell differentiation; regulation of transcription, DNA-templated; monocyte differentiation; transcription by RNA polymerase II; transcription, DNA-templated; digestion; regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	8544
	69656
	ENSG00000087842
	ENSMUSG00000031379
	O00625
	Q9D711
	NM_003662; NM_001018109
	NM_001301402; NM_027153
	NP_001018119; NP_003653
	NP_001288331; NP_081429
	Wikidata
View/Edit Human	View/Edit Mouse

Pirin is a protein that in humans is encoded by the PIR gene.^[5]^[6]

This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.^[6]

Interactions

PIR (gene) has been shown to interact with BCL3.^[7]

Pirin in Bacteria

The pir gene is conserved in both bacteria and eukaryotes. In Pseudomonas stutzeri this protein exhibited quercetinase activity.^[8] In Streptomyces ambofaciens, a strain known to produce the antibiotic spiramycin, the pirA gene regulates the AcdB enzyme that catalyzes one of the first steps of beta-oxidation.^[9] Loss of the pirA gene causes a metabolic imbalance that reduces the amount of antibiotic produced.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000087842 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031379 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wendler WM, Kremmer E, Forster R, Winnacker EL (May 1997). "Identification of pirin, a novel highly conserved nuclear protein". J Biol Chem. 272 (13): 8482–9. doi:10.1074/jbc.272.13.8482. PMID 9079676.
^ ^a ^b "Entrez Gene: PIR pirin (iron-binding nuclear protein)".
^ Dechend, R; Hirano F; Lehmann K; Heissmeyer V; Ansieau S; Wulczyn F G; Scheidereit C; Leutz A (Jun 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. ISSN 0950-9232. PMID 10362352.
^ Widiatningrum, Talitha; Maeda, Sorato; Kataoka, Kunishige; Sakurai, Takeshi (2015-08-07). "A pirin-like protein from Pseudomonas stutzeri and its quercetinase activity". Biochemistry and Biophysics Reports. 3: 144–149. doi:10.1016/j.bbrep.2015.08.001. ISSN 2405-5808. PMC 5668851. PMID 29124178.
^ ^a ^b Talà, Adelfia; Damiano, Fabrizio; Gallo, Giuseppe; Pinatel, Eva; Calcagnile, Matteo; Testini, Mariangela; Fico, Daniela; Rizzo, Daniela; Sutera, Alberto; Renzone, Giovanni; Scaloni, Andrea; De Bellis, Gianluca; Siculella, Luisa; De Benedetto, Giuseppe Egidio; Puglia, Anna Maria (July 2018). "Pirin: A novel redox-sensitive modulator of primary and secondary metabolism in Streptomyces". Metabolic Engineering. 48: 254–268. doi:10.1016/j.ymben.2018.06.008. ISSN 1096-7184. PMID 29944936.

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Adams M, Jia Z (2005). "Structural and biochemical analysis reveal pirins to possess quercetinase activity". J. Biol. Chem. 280 (31): 28675–82. doi:10.1074/jbc.M501034200. PMID 15951572.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Pang H, Bartlam M, Zeng Q, et al. (2004). "Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor". J. Biol. Chem. 279 (2): 1491–8. doi:10.1074/jbc.M310022200. PMID 14573596.
Zeng Q, Li X, Bartlam M, et al. (2004). "Purification, crystallization and preliminary X-ray analysis of human pirin". Acta Crystallogr. D. 59 (Pt 8): 1496–8. doi:10.1107/S0907444903012289. PMID 12876364.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Dechend R, Hirano F, Lehmann K, et al. (1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. PMID 10362352.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000087842 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031379 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9079676-5] Wendler WM, Kremmer E, Forster R, Winnacker EL (May 1997). "Identification of pirin, a novel highly conserved nuclear protein". J Biol Chem. 272 (13): 8482–9. doi:10.1074/jbc.272.13.8482. PMID 9079676.

[entrez-6] "Entrez Gene: PIR pirin (iron-binding nuclear protein)".

[pmid10362352-7] Dechend, R; Hirano F; Lehmann K; Heissmeyer V; Ansieau S; Wulczyn F G; Scheidereit C; Leutz A (Jun 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. ISSN 0950-9232. PMID 10362352.

[8] Widiatningrum, Talitha; Maeda, Sorato; Kataoka, Kunishige; Sakurai, Takeshi (2015-08-07). "A pirin-like protein from Pseudomonas stutzeri and its quercetinase activity". Biochemistry and Biophysics Reports. 3: 144–149. doi:10.1016/j.bbrep.2015.08.001. ISSN 2405-5808. PMC 5668851. PMID 29124178.

[:0-9] Talà, Adelfia; Damiano, Fabrizio; Gallo, Giuseppe; Pinatel, Eva; Calcagnile, Matteo; Testini, Mariangela; Fico, Daniela; Rizzo, Daniela; Sutera, Alberto; Renzone, Giovanni; Scaloni, Andrea; De Bellis, Gianluca; Siculella, Luisa; De Benedetto, Giuseppe Egidio; Puglia, Anna Maria (July 2018). "Pirin: A novel redox-sensitive modulator of primary and secondary metabolism in Streptomyces". Metabolic Engineering. 48: 254–268. doi:10.1016/j.ymben.2018.06.008. ISSN 1096-7184. PMID 29944936.

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PIR (gene)

Interactions

Pirin in Bacteria

References

Further reading