PLCB2

PLCB2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPLCB2, PLC-beta-2, phospholipase C beta 2
External IDsOMIM: 604114; MGI: 107465; HomoloGene: 20957; GeneCards: PLCB2; OMA:PLCB2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001284297
NM_001284298
NM_001284299
NM_004573

NM_001290790
NM_177568

RefSeq (protein)

NP_001271226
NP_001271227
NP_001271228
NP_004564

NP_001277719
NP_808236

Location (UCSC)Chr 15: 40.28 – 40.31 MbChr 2: 118.54 – 118.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 is an enzyme that in humans is encoded by the PLCB2 gene.[5][6][7]

Function

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The gene codes for the enzyme phospholipase C β2. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.

Interactions

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PLCB2 has been shown to interact with MAP2K3[8] and TRPM7.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137841Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040061Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Park D, Jhon DY, Kriz R, Knopf J, Rhee SG (Sep 1992). "Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2". J. Biol. Chem. 267 (23): 16048–55. doi:10.1016/S0021-9258(18)41963-1. PMID 1644792.
  6. ^ Park SH, Ryu SH, Suh PG, Kim H (Mar 1999). "Assignment1 of human PLCB2 encoding PLC beta2 to human chromosome 15q15 by fluorescence in situ hybridization". Cytogenet. Cell Genet. 83 (1–2): 48–9. doi:10.1159/000015166. PMID 9925923. S2CID 45169136.
  7. ^ "Entrez Gene: PLCB2 phospholipase C, beta 2".
  8. ^ Barr AJ, Marjoram R, Xu J, Snyderman R (Apr 2002). "Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3". Biochem. Biophys. Res. Commun. 293 (1): 647–52. doi:10.1016/S0006-291X(02)00259-0. PMID 12054652.
  9. ^ Runnels LW, Yue L, Clapham DE (May 2002). "The TRPM7 channel is inactivated by PIP(2) hydrolysis". Nat. Cell Biol. 4 (5): 329–36. doi:10.1038/ncb781. PMID 11941371. S2CID 21592843.

Further reading

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