PPP3CC

PPP3CC
Identifiers
AliasesPPP3CC, CALNA3, CNA3, PP2Bgamma, protein phosphatase 3 catalytic subunit gamma
External IDsOMIM: 114107; MGI: 107162; HomoloGene: 68475; GeneCards: PPP3CC; OMA:PPP3CC - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001243974
NM_001243975
NM_005605

NM_008915
NM_001304991
NM_001304992
NM_001360229

RefSeq (protein)

NP_001230903
NP_001230904
NP_005596

NP_001291920
NP_001291921
NP_032941
NP_001347158

Location (UCSC)Chr 8: 22.44 – 22.54 MbChr 14: 70.22 – 70.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PP2BC) is an enzyme that in humans is encoded by the PPP3CC gene.[5][6]

Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status.

In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively.

At least 3 genes, calcineurin A-alpha (CALNA1; MIM 114105), calcineurin A-beta (CALNA2; MIM 114106), and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).[supplied by OMIM][6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120910Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022092Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Muramatsu T, Kincaid RL (Nov 1992). "Molecular cloning and chromosomal mapping of the human gene for the testis-specific catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A)". Biochem Biophys Res Commun. 188 (1): 265–71. doi:10.1016/0006-291X(92)92379-C. PMID 1339277.
  6. ^ a b "Entrez Gene: PPP3CC protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform".

Further reading

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