After the opening of the Portal de Usme in early 2001, the Autopista Norte line was opened. This station was added as a northerly expansion of that line, which was completed with the opening of the Portal del Norte later that year.
The station is named Pepe Sierra due to its proximity to Calle 116, known as Avenida Pepe Sierra named after businessman José María Sierra.
End June 2003, an explosive went off on a bus arriving at this station. 70 passengers were able to get off before the articulated bus burned.