Phenicarbazide

Phenicarbazide
Clinical data
Other names1-Phenylsemicarbazide; Kryogenin
ATC code
  • none
Identifiers
  • 2-Phenylhydrazinecarboxamide
CAS Number
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.002.794 Edit this at Wikidata
Chemical and physical data
FormulaC7H9N3O
Molar mass151.169 g·mol−1
  • InChI=1S/C7H9N3O/c8-7(11)10-9-6-4-2-1-3-5-6/h1-5,9H,(H3,8,10,11) checkY
  • Key:AVKHCKXGKPAGEI-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Phenicarbazide is a semicarbazide and an antipyretic substance. It is carcinogenic in mice.[1]

Preparation

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Phenicarbazide can be obtained by mixing phenylhydrazine with acetic acid in aqueous solution with the addition of potassium cyanide. It is also obtained from the reaction of phenylhydrazine with urea.[2]

Properties

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Phenicarbazide is a flammable, hard to ignite, crystalline, beige solid that is practically insoluble in water. It decomposes on heating.[3]

Uses

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Phenicarbazide is an intermediate in the syntheses of a series of chemical compounds by cyclocondensation reactions.[4] It was investigated as an analgesic and antipyretic in the 1970s and was used in combination preparations.

References

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  1. ^ "Phenicarbazide". International Agency for Research on Cancer (IARC) - Summaries & Evaluations. 25 March 1998.
  2. ^ Bruchhausen F, Ebel S, Hackenthal E, Holzgrabe U, Albinus M, Amschler G, Angerer E (1999). Hagers Handbuch der Pharmazeutischen Praxis : Stoffe L-Z Folgeband 5 (5. vollständig neubearbeitete Auflage ed.). Berlin, Heidelberg. p. 420. ISBN 978-3-642-58388-9. OCLC 913646782.{{cite book}}: CS1 maint: location missing publisher (link)
  3. ^ "Phenicarbazid". GESTIS-Stoffdatenbank. Retrieved 2022-10-18.
  4. ^ "1-Phenylsemicarbazide". Sigma-Aldrich.