Phthalide

Phthalide
Names
	Preferred IUPAC name 2-Benzofuran-1(3H)-one
	Other names Phthalolactone
Identifiers
CAS Number	87-41-2 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:38085;
ChemSpider	6621;
ECHA InfoCard	100.001.586
PubChem CID	6885;
UNII	8VV922U86J;
CompTox Dashboard (EPA)	DTXSID0052594 ;
	InChI InChI=1S/C8H6O2/c9-8-7-4-2-1-3-6(7)5-10-8/h1-4H,5H2 Key: WNZQDUSMALZDQF-UHFFFAOYSA-N; InChI=1/C8H6O2/c9-8-7-4-2-1-3-6(7)5-10-8/h1-4H,5H2 Key: WNZQDUSMALZDQF-UHFFFAOYAW;
	SMILES O=C1OCc2ccccc12;
Properties
Chemical formula	C8H6O2
Molar mass	134.134 g·mol−1
Melting point	75 to 77 °C (167 to 171 °F; 348 to 350 K)
Boiling point	290 °C (554 °F; 563 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Phthalide is an organic chemical compound with the molecular formula C₈H₆O₂. It is a white solid and the simplest benzo lactone. It is prepared from hydroxymethylbenzoic acid.^[3]

Phthalides

The phthalide core is found a variety of more complex chemical compounds including dyes (such as phenolphthalein), fungicides (such as tetrachlorophthalide, often referred to simply as "phthalide"), and natural oils (such as butylphthalide).

Examples

References

^ Kumar, R. Arun; Maheswari, C. Uma; Ghantasala, Satheesh; Jyothi, C.; Reddy, K. Rajender (2011). "Synthesis of 3H-Quinazolin-4-ones and 4H-3,1-Benzoxazin-4-ones via Benzylic Oxidation and Oxidative Dehydrogenation using Potassium Iodide-tert-Butyl Hydroperoxide". Advanced Synthesis & Catalysis. 353 (2+3): 401–410. doi:10.1002/adsc.201000580.
^ Kus, Nermin Simsek (2008). "Some oxidation reactions with molecular oxygen in subcritical water". Asian Journal of Chemistry. 20 (2): 1226–1230.
^ J. H. Gardner, C. A. Naylor, Jr (1936). "Phthalide". Organic Syntheses. 16: 71. doi:10.15227/orgsyn.016.0071.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[1] Kumar, R. Arun; Maheswari, C. Uma; Ghantasala, Satheesh; Jyothi, C.; Reddy, K. Rajender (2011). "Synthesis of 3H-Quinazolin-4-ones and 4H-3,1-Benzoxazin-4-ones via Benzylic Oxidation and Oxidative Dehydrogenation using Potassium Iodide-tert-Butyl Hydroperoxide". Advanced Synthesis & Catalysis. 353 (2+3): 401–410. doi:10.1002/adsc.201000580.

[2] Kus, Nermin Simsek (2008). "Some oxidation reactions with molecular oxygen in subcritical water". Asian Journal of Chemistry. 20 (2): 1226–1230.

[3] J. H. Gardner, C. A. Naylor, Jr (1936). "Phthalide". Organic Syntheses. 16: 71. doi:10.15227/orgsyn.016.0071.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[1]

[2]

[3]

Names

Preferred IUPAC name 2-Benzofuran-1(3H)-one
Other names Phthalolactone
Identifiers
CAS Number	87-41-2^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:38085
ChemSpider	6621
ECHA InfoCard	100.001.586
PubChem CID	6885
UNII	8VV922U86J
CompTox Dashboard (EPA)	DTXSID0052594
InChI InChI=1S/C8H6O2/c9-8-7-4-2-1-3-6(7)5-10-8/h1-4H,5H2 Key: WNZQDUSMALZDQF-UHFFFAOYSA-N InChI=1/C8H6O2/c9-8-7-4-2-1-3-6(7)5-10-8/h1-4H,5H2 Key: WNZQDUSMALZDQF-UHFFFAOYAW
SMILES O=C1OCc2ccccc12
Properties
Chemical formula	C₈H₆O₂
Molar mass	134.134 g·mol⁻¹
Melting point	75 to 77 °C (167 to 171 °F; 348 to 350 K)^[1]
Boiling point	290 °C (554 °F; 563 K)^[2]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references