Protein-coding gene in the species Homo sapiens
Rap1 GTPase-activating protein 1 is an enzyme that in humans is encoded by the RAP1GAP gene .[ 5] [ 6]
RAP1GAP has been shown to interact with MLLT4 .[ 7]
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"Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1" . The Journal of Biological Chemistry . 271 (47): 29903–8. doi :10.1074/jbc.271.47.29903 PMID 8939933 . Kurachi H, Wada Y, Tsukamoto N, Maeda M, Kubota H, Hattori M, Iwai K, Minato N (October 1997). "Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product" . The Journal of Biological Chemistry . 272 (44): 28081–8. doi :10.1074/jbc.272.44.28081 PMID 9346962 . Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (October 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain" . DNA Research . 4 (5): 345–9. doi :10.1093/dnares/4.5.345 PMID 9455484 . Mochizuki N, Ohba Y, Kiyokawa E, Kurata T, Murakami T, Ozaki T, Kitabatake A, Nagashima K, Matsuda M (August 1999). "Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i)". Nature . 400 (6747): 891–4. Bibcode :1999Natur.400..891M . doi :10.1038/23738 . PMID 10476970 . S2CID 204995543 . Meng J, Glick JL, Polakis P, Casey PJ (December 1999). "Functional interaction between Galpha(z) and Rap1GAP suggests a novel form of cellular cross-talk" . The Journal of Biological Chemistry . 274 (51): 36663–9. doi :10.1074/jbc.274.51.36663 PMID 10593970 . Berruti G (May 2000). "A novel rap1/B-Raf/14-3-3 theta protein complex is formed in vivo during the morphogenetic differentiation of postmeiotic male germ cells". Experimental Cell Research . 257 (1): 172–9. doi :10.1006/excr.2000.4877 . PMID 10854065 . Kao S, Jaiswal RK, Kolch W, Landreth GE (May 2001). "Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells" . The Journal of Biological Chemistry . 276 (21): 18169–77. doi :10.1074/jbc.M008870200 PMID 11278445 . Klinger M, Kudlacek O, Seidel MG, Freissmuth M, Sexl V (September 2002). "MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases" . The Journal of Biological Chemistry . 277 (36): 32490–7. doi :10.1074/jbc.M200556200 PMID 12082090 . Liu L, Schwartz BR, Tupper J, Lin N, Winn RK, Harlan JM (October 2002). "The GTPase Rap1 regulates phorbol 12-myristate 13-acetate-stimulated but not ligand-induced beta 1 integrin-dependent leukocyte adhesion" . The Journal of Biological Chemistry . 277 (43): 40893–900. doi :10.1074/jbc.M206208200 PMID 12091396 . de Bruyn KM, Rangarajan S, Reedquist KA, Figdor CG, Bos JL (August 2002). "The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion" . The Journal of Biological Chemistry . 277 (33): 29468–76. doi :10.1074/jbc.M204990200 hdl :2066/142510 PMID 12171996 . 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