RSU1

RSU1
Identifiers
Aliases	RSU1, RSP-1, Ras suppressor protein 1
External IDs	OMIM: 179555; MGI: 103040; HomoloGene: 7521; GeneCards: RSU1; OMA:RSU1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	16,817,463 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	13,276,226 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; right coronary artery; ; left coronary artery; ; Descending thoracic aorta; ; ascending aorta; ; Achilles tendon; ; monocyte; ; saphenous vein; ; stromal cell of endometrium;
	Top expressed in
	genital tubercle; ; granulocyte; ; ascending aorta; ; umbilical cord; ; calvaria; ; external carotid artery; ; tail of embryo; ; endothelial cell of lymphatic vessel; ; left lung lobe; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytosol; extracellular exosome; focal adhesion;
Biological process	positive regulation of GTPase activity; regulation of cell-substrate adhesion; signal transduction; positive regulation of cell-substrate adhesion;
	Sources:Amigo / QuickGO
Orthologs
	6251
	20163
	ENSG00000148484
	ENSMUSG00000026727
	Q15404
	Q01730
	NM_012425; NM_152724
	NM_009105
	NP_036557; NP_689937
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Ras suppressor protein 1 is a protein that in humans is encoded by the RSU1 gene.^[5]^[6]

This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors.^[6] RSU-1 has also been seen to act as a structural protein in integrin-mediated focal-adhesion complexes. It bind strongly to the protein PINCH.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148484 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026727 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tsuda T, Cutler ML (Feb 1994). "Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human chromosome 10". Genomics. 18 (2): 461–2. doi:10.1006/geno.1993.1503. PMID 8288261.
^ ^a ^b "Entrez Gene: RSU1 Ras suppressor protein 1".

Cutler ML, Bassin RH, Zanoni L, Talbot N (1992). "Isolation of rsp-1, a novel cDNA capable of suppressing v-Ras transformation". Mol. Cell. Biol. 12 (9): 3750–6. doi:10.1128/MCB.12.9.3750. PMC 360236. PMID 1508180.
Tsuda T, Marinetti MR, Masuelli L, Cutler ML (1995). "The Ras suppressor RSU-1 localizes to 10p13 and its expression in the U251 glioblastoma cell line correlates with a decrease in growth rate and tumorigenic potential". Oncogene. 11 (2): 397–403. PMID 7624154.
Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Masuelli L, Cutler ML (1996). "Increased expression of the Ras suppressor Rsu-1 enhances Erk-2 activation and inhibits Jun kinase activation". Mol. Cell. Biol. 16 (10): 5466–76. doi:10.1128/MCB.16.10.5466. PMC 231547. PMID 8816460.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chunduru S, Kawami H, Gullick R, et al. (2003). "Identification of an alternatively spliced RNA for the Ras suppressor RSU-1 in human gliomas". J. Neurooncol. 60 (3): 201–11. doi:10.1023/A:1021130620178. PMID 12510772. S2CID 34539.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes". Biochem. J. 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMC 1134064. PMID 15242332.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Dougherty GW, Chopp T, Qi SM, Cutler ML (2005). "The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions". Exp. Cell Res. 306 (1): 168–79. doi:10.1016/j.yexcr.2005.01.025. PMID 15878342.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148484 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026727 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8288261-5] Tsuda T, Cutler ML (Feb 1994). "Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human chromosome 10". Genomics. 18 (2): 461–2. doi:10.1006/geno.1993.1503. PMID 8288261.

[entrez-6] "Entrez Gene: RSU1 Ras suppressor protein 1".

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RSU1

References

Further reading