Mammaglobin-A

SCGB2A2
Identifiers
AliasesSCGB2A2, MGB1, UGB2, secretoglobin family 2A member 2, PSBP1
External IDsOMIM: 605562; HomoloGene: 82995; GeneCards: SCGB2A2; OMA:SCGB2A2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002411

XM_006527538

RefSeq (protein)

NP_002402

NP_001365339

Location (UCSC)Chr 11: 62.27 – 62.27 MbChr 19: 9.85 – 9.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mammaglobin-A also known as secretoglobin family 2A member 2 is a protein that in humans is encoded by the SCGB2A2 gene.[5][6][7]

Function

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SCGB2A2 is a member of the superfamily of secretoglobins, a group of small dimeric secreted and sometimes glycosylated proteins. Expressed mainly in mucosa, secretoglobins seem to be involved in cell signalling, immune response, and chemotaxis, and may also serve as transporters for steroid hormones in humans.[8]

Clinical significance

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SCGB2A2 expression is highly specific of mammary tissue, and is increasingly used for identification and detection of disseminated breast cancer cells.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000110484Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000096872Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Watson MA, Darrow C, Zimonjic DB, Popescu NC, Fleming TP (Mar 1998). "Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13". Oncogene. 16 (6): 817–24. doi:10.1038/sj.onc.1201597. PMID 9488047.
  6. ^ Watson MA, Fleming TP (Jul 1996). "Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer". Cancer Res. 56 (4): 860–5. PMID 8631025.
  7. ^ "Entrez Gene: SCGB2A2 secretoglobin, family 2A, member 2".
  8. ^ Brown NM, Stenzel TT, Friedman PN, Henslee J, Huper G, Marks JR (2006). "Evaluation of expression based markers for the detection of breast cancer cells". Breast Cancer Research and Treatment. 97 (1): 41–47. doi:10.1007/s10549-005-9085-8. PMID 16319979. S2CID 22307616.
  9. ^ Lacroix M (2006). "Significance, detection and markers of disseminated breast cancer cells". Endocrine-Related Cancer. 13 (4). Bioscientifica: 1033–1067. doi:10.1677/ERC-06-0001. PMID 17158753. S2CID 10708900.

Further reading

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