Protein-coding gene in the species Homo sapiens
SEC14L2 is a gene that, in humans, encodes the protein SEC14-like protein 2 .[ 5] [ 6]
This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein , and cellular retinol-binding protein . The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in metabolism of cholesterol .[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000100003 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003585 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22" . Nature . 402 (6761): 489–95. Bibcode :1999Natur.402..489D . doi :10.1038/990031 PMID 10591208 . ^ a b "Entrez Gene: SEC14L2 SEC14-like 2 (S. cerevisiae)" . Caras IW, Friedlander EJ, Bloch K (1980). 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"Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis" . Proc. Natl. Acad. Sci. U.S.A . 98 (5): 2244–9. Bibcode :2001PNAS...98.2244S . doi :10.1073/pnas.041620398 PMC 30123 PMID 11226224 . Hirosawa M, Nagase T, Murahashi Y, Kikuno R, Ohara O (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping" . DNA Res . 8 (1): 1–9. doi :10.1093/dnares/8.1.1 PMID 11258795 . Yamauchi J, Iwamoto T, Kida S, Masushige S, Yamada K, Esashi T (2001). "Tocopherol-associated protein is a ligand-dependent transcriptional activator". Biochem. Biophys. Res. Commun . 285 (2): 295–9. doi :10.1006/bbrc.2001.5162 . PMID 11444841 . Stocker A, Tomizaki T, Schulze-Briese C, Baumann U (2003). "Crystal structure of the human supernatant protein factor" . Structure . 10 (11): 1533–40. doi :10.1016/S0969-2126(02)00884-5 PMID 12429094 . 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PDB gallery
1o6u : THE CRYSTAL STRUCTURE OF HUMAN SUPERNATANT PROTEIN FACTOR
1olm : SUPERNATANT PROTEIN FACTOR IN COMPLEX WITH RRR-ALPHA-TOCOPHERYLQUINONE: A LINK BETWEEN OXIDIZED VITAMIN E AND CHOLESTEROL BIOSYNTHESIS
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