SNAP29

SNAP29
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSNAP29, CEDNIK, SNAP-29, synaptosome associated protein 29kDa, synaptosome associated protein 29
External IDsOMIM: 604202; MGI: 1914724; HomoloGene: 3512; GeneCards: SNAP29; OMA:SNAP29 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004782

NM_023348

RefSeq (protein)

NP_004773

NP_075837

Location (UCSC)Chr 22: 20.86 – 20.89 MbChr 16: 17.22 – 17.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptosomal-associated protein 29 is a protein that in humans is encoded by the SNAP29 gene.[5][6][7]

Function

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This gene, a member of the SNAP25 gene family, encodes a protein involved in multiple membrane trafficking steps. Two other members of this gene family, SNAP23 and SNAP25, encode proteins that bind a syntaxin protein and mediate synaptic vesicle membrane docking and fusion to the plasma membrane. The protein encoded by this gene binds tightly to multiple syntaxins and is localized to intracellular membrane structures rather than to the plasma membrane. While the protein is mostly membrane-bound, a significant fraction of it is found free in the cytoplasm. Use of multiple polyadenylation sites has been noted for this gene.[7]

Interactions

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SNAP29 has been shown to interact with Syntaxin 3[5] and EHD1.[8]

SNAP29 was shown to interact with CVB3 and EV-D68 viral protease 3C.[9][10]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099940Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022765Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (January 1999). "Three novel proteins of the syntaxin/SNAP-25 family". J Biol Chem. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
  6. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  7. ^ a b "Entrez Gene: SNAP29 synaptosomal-associated protein, 29kDa".
  8. ^ Rotem-Yehudar R, Galperin E, Horowitz M (August 2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29". J. Biol. Chem. 276 (35): 33054–60. doi:10.1074/jbc.M009913200. PMID 11423532.
  9. ^ Mohamud, Yasir; Shi, Junyan; Qu, Junyan; Poon, Tak; Xue, Yuan Chao; Deng, Haoyu; Zhang, Jingchun; Luo, Honglin (2018-03-20). "Enteroviral Infection Inhibits Autophagic Flux via Disruption of the SNARE Complex to Enhance Viral Replication". Cell Reports. 22 (12): 3292–3303. doi:10.1016/j.celrep.2018.02.090. ISSN 2211-1247. PMID 29562184.
  10. ^ Corona, Abigail K.; Saulsbery, Holly M.; Corona Velazquez, Angel F.; Jackson, William T. (2018-03-20). "Enteroviruses Remodel Autophagic Trafficking through Regulation of Host SNARE Proteins to Promote Virus Replication and Cell Exit". Cell Reports. 22 (12): 3304–3314. doi:10.1016/j.celrep.2018.03.003. ISSN 2211-1247. PMC 5894509. PMID 29562185.

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: O95721 (Synaptosomal-associated protein 29) at the PDBe-KB.