Protein-coding gene in the species Homo sapiens
Transportin-3 is a protein that in humans is encoded by the TNPO3 gene .[ 5] [ 6] [ 7]
TNPO3 is a nuclear import receptor for serine/arginine-rich (SR) proteins, including Serine/arginine-rich splicing factor 1 , which are essential precursor-mRNA splicing factors .[ 5] [ 7]
Clinical significance [ edit ] The TNPO3-IRF5 locus is implicated in primary biliary cirrhosis and systemic sclerosis .[ 8]
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